{"created":"2023-06-20T15:47:50.999997+00:00","id":2378,"links":{},"metadata":{"_buckets":{"deposit":"30d2c932-7fd1-4873-aa9a-f136e1365c45"},"_deposit":{"created_by":4,"id":"2378","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"2378"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00002378","sets":["1:11"]},"author_link":[],"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1994-06-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"208","bibliographicPageStart":"201","bibliographicVolumeNumber":"38","bibliographic_titles":[{"bibliographic_title":"生物物理化学"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Fourteen individuals with low serum cholinesterase activity were examined by genetic analysis. All of these were considered to be due to silent gene because their dibucaine number and fluoride number were similar to reference values. PCR-SSCP analysis and following direct DNA sequencing analysis disclosed five missense or nonsense mutations in 11 individuals: 2 individuals with C to T mutation at codon 24 (Thr to Met), 2 individuals with G to C mutation at codon 365  (Gly to Arg), 3 individuals with T to A mutation at codon 330 (Leu to Ile), 1 individual with C to T mutation at codon 119 (Gln to stop) and 3 individuals with C to T mutation at codon 515 (Arg to Cys). For K variant, 3 homozygous individuals and 8 heterozygous individuals were determined. All of 14 individuals with low serum cholinesterase activity revealed genetic mutation in cholinesterase gene. Therefore, we should be aware of the existence of genetic mutations causing hypocholinesterasemia in laboratory diagnosis.","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本電気泳動学会"}]},"item_3_relation_28":{"attribute_name":"出版社DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.2198/sbk.38.201","subitem_relation_type_select":"DOI"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"日本電気泳動学会"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00319082","subitem_source_identifier_type":"ISSN"}]},"item_3_source_id_20":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"13499785","subitem_source_identifier_type":"ISSN"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"前川, 真人"}]},{"creatorNames":[{"creatorName":"須藤, 加代子"}]},{"creatorNames":[{"creatorName":"Dilip, Chandra  Dey"}]},{"creatorNames":[{"creatorName":"小谷, 一夫"}]},{"creatorNames":[{"creatorName":"石川, 仁子"}]},{"creatorNames":[{"creatorName":"泉, 正和"}]},{"creatorNames":[{"creatorName":"臼田, 多佳志"}]},{"creatorNames":[{"creatorName":"菅野, 剛史"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-08-27"}],"displaytype":"detail","filename":"Seibutubuturi38-201.pdf","filesize":[{"value":"5.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Seibutubuturi38-201.pdf","url":"https://hama-med.repo.nii.ac.jp/record/2378/files/Seibutubuturi38-201.pdf"},"version_id":"d98e3fbe-c526-4cf2-922e-e27929afcb02"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"polymerase chain reaction (PCR)","subitem_subject_scheme":"Other"},{"subitem_subject":"single strand conformation polymorphism (SSCP),","subitem_subject_scheme":"Other"},{"subitem_subject":"genetic mutation","subitem_subject_scheme":"Other"},{"subitem_subject":"serum cholinesterase","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"低コリンエステラーゼ血症例における変異遺伝子の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"低コリンエステラーゼ血症例における変異遺伝子の解析","subitem_title_language":"ja"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2011-04-12"},"publish_date":"2011-04-12","publish_status":"0","recid":"2378","relation_version_is_last":true,"title":["低コリンエステラーゼ血症例における変異遺伝子の解析"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-08-02T05:00:12.232121+00:00"}