{"created":"2023-06-20T15:47:53.249838+00:00","id":2410,"links":{},"metadata":{"_buckets":{"deposit":"65fcbda6-7f39-4421-abf2-c4ea810878cb"},"_deposit":{"created_by":4,"id":"2410","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"2410"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00002410","sets":["1:11"]},"author_link":[],"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1981-06-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"359","bibliographicPageStart":"349","bibliographicVolumeNumber":"23","bibliographic_titles":[{"bibliographic_title":"Japanese Heart Journal"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The therapeutic effect of L-carnitine on arrhythmias during hemodialysis was evaluated in 17 patients with chronic renal disease undergoing intermittent hemodialysis. In 11 of 17 patients (65%), ventricular or supraventricular premature beats appeared at 20 to 30min after the start of hemodialysis and continued throughout the dialysis. Plasma carnitine was at a lower level in the predialysis period (24.8±7.9n mole/ml) as compared with the normal human levels (46.1±8.6n mole/ml), and decreased markedly by the end of dialysis (8.2±5.9n mole/ml). Plasma free fatty acids rapidly increased immediately after the start of dialysis, reached the maximum levels after 20min (from 0.23±0.09 to 1.31±0.64mEq/L) and maintained higher levels even at the end of dialysis (0.76± 0.29mEq/L). Administration of L-carnitine (2Gm orally), 2 hours before the start of dialysis, maintained plasma carnitine within normal levels throughout the dialysis and suppressed the increase in plasma free fatty acids. Both the incidence and the severity of premature beats during hemodialysis were significantly reduced by oral administration of L-carnitine (2Gm daily) for 4 to 8 weeks. These results suggest that L-carnitine is useful for the treatment of hemodialysis arrhythmias, presumably by restoring impaired oxidation of free fatty acids.","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"International Heart Journal Association"}]},"item_3_relation_28":{"attribute_name":"出版社DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1536/ihj.23.349","subitem_relation_type_select":"DOI"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"by International Heart Journal Association"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00214868","subitem_source_identifier_type":"ISSN"}]},"item_3_source_id_20":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"1348673X","subitem_source_identifier_type":"ISSN"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Suzuki, Yoshikazu"}]},{"creatorNames":[{"creatorName":"Narita, Masayasu"}]},{"creatorNames":[{"creatorName":"Yamazaki, Noboru"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-08-27"}],"displaytype":"detail","filename":"JHeartJ-23-349.pdf","filesize":[{"value":"444.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JHeartJ-23-349.pdf","url":"https://hama-med.repo.nii.ac.jp/record/2410/files/JHeartJ-23-349.pdf"},"version_id":"add80fa1-5096-4cf9-acff-06cca1564ca5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Holter electrocardiography","subitem_subject_scheme":"Other"},{"subitem_subject":"High plasma free fatty acids","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effects of L-Carnitine on Arrhythmias during Hemodialysis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of L-Carnitine on Arrhythmias during Hemodialysis","subitem_title_language":"en"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-08-27"},"publish_date":"2013-08-27","publish_status":"0","recid":"2410","relation_version_is_last":true,"title":["Effects of L-Carnitine on Arrhythmias during Hemodialysis"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-08-02T05:01:35.236230+00:00"}