{"created":"2023-06-20T15:47:53.587589+00:00","id":2415,"links":{},"metadata":{"_buckets":{"deposit":"89e824e0-c8cc-43df-9040-320ac667273e"},"_deposit":{"created_by":4,"id":"2415","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"2415"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00002415","sets":["1:11"]},"author_link":[],"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1979-07-13","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"407","bibliographicPageStart":"399","bibliographicVolumeNumber":"21","bibliographic_titles":[{"bibliographic_title":"Japanese Heart Journal"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Because the mechanism of adverse reactions to abrupt cessation of propranolol in patients with coronary heart disease was an enigma, we studied the effect of cessation of propranolol on beta-adrenergic receptor reactivity to catecholamine stimulation. The cyclic AMP concentrations in plasma and left ventricular muscle after the administration of isoproterenol  (5mg/Kg) were measured in rats before, during, 2 days after, and 4 days after of the administration of propranolol (5mg/Kg). Two days after withdrawal from propranolol, the cyclic AMP concentrations in plasma and left ventricular muscle were significantly increased (p<0.005, p<0.01). Four days after withdrawal from propranolol, the cyclic AMP concentration in plasma was significantly increased (p<0.001). On the other hand, that of left ventricular muscle showed a tendency to have higher value, although, this was statistically not significant. From these results, this study supports that there is a hypersensitivity to adrenergic stimulation after abrupt cessation of long-term propranolol treatment. The explanation of propranolol withdrawal phenomenon most likely lies in the nature of beta adrenergic receptors that become activated during long-term blockade.","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"International Heart Journal Association"}]},"item_3_relation_28":{"attribute_name":"出版社DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1536/ihj.21.399","subitem_relation_type_select":"DOI"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"by International Heart Journal Association"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00214868","subitem_source_identifier_type":"ISSN"}]},"item_3_source_id_20":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"1348673X","subitem_source_identifier_type":"ISSN"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kobayashi, Akira"}]},{"creatorNames":[{"creatorName":"Ogawa, Kohichi"}]},{"creatorNames":[{"creatorName":"Yamazaki, Noboru"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-08-27"}],"displaytype":"detail","filename":"JHeartJ-21-399.pdf","filesize":[{"value":"531.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JHeartJ-21-399.pdf","url":"https://hama-med.repo.nii.ac.jp/record/2415/files/JHeartJ-21-399.pdf"},"version_id":"0c79db84-d7d0-4fcf-84ad-6ff4ebbaad7d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Propranolol withdrawal syndrome","subitem_subject_scheme":"Other"},{"subitem_subject":"Beta adrenergic receptor","subitem_subject_scheme":"Other"},{"subitem_subject":"Hyperadrenergic state","subitem_subject_scheme":"Other"},{"subitem_subject":"Cyclic AMP","subitem_subject_scheme":"Other"},{"subitem_subject":"Isoproterenol","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Changes of Cyclic AMP Concentration to Isoproterenol after Abrupt Cessation of Propranolol in Rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Changes of Cyclic AMP Concentration to Isoproterenol after Abrupt Cessation of Propranolol in Rats","subitem_title_language":"en"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-08-27"},"publish_date":"2013-08-27","publish_status":"0","recid":"2415","relation_version_is_last":true,"title":["Changes of Cyclic AMP Concentration to Isoproterenol after Abrupt Cessation of Propranolol in Rats"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-08-02T05:01:49.437282+00:00"}