{"created":"2023-06-20T15:47:54.425816+00:00","id":2425,"links":{},"metadata":{"_buckets":{"deposit":"5fb00dbb-eddf-46b7-9416-5ab02ae23736"},"_deposit":{"created_by":4,"id":"2425","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"2425"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00002425","sets":["1:11"]},"author_link":[],"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1981-03-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"368","bibliographicPageStart":"361","bibliographicVolumeNumber":"137","bibliographic_titles":[{"bibliographic_title":"The Tohoku Journal of Experimental Medicine"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The effect of thymoxamine, a pure alpha-adrenoceptor blocking agent, on ouabain-induced arrhythmias was investigated in dogs to clarify whether thymoxamine has an arrhythmogenic or an anti-arrhythmic action. Thymoxamine, 1mg/kg i.v., inhibited the manifestation of ventricular arrhythmias (VA) and the pressor effect produced by ouabain infusion (1μg/kg/min i.v.) as 5mg/ kg i.v. of phentolamine did. Low doses of these drugs did not affect the VA. Simultaneous infusion of phenylephrine (5μg/kg/min i.v.) with ouabain enhanced the manifestation of VA accompanying pressor effects, which were inhibited by thymoxamine (1mg/kg) in a parallel manner. Infusion of isoprenaline (0.2μg/ kg/min i.v.) with ouabain enhanced the manifestation of VA, but the enhancement was to a lesser extent than with phenylephrine. Thymoxamine, 1mg/kg, did not affect the VA. The infusion of CaCl2 (20mg/kg/min i.v.) with ouabain enhanced the manifestation of VA, which was not inhibited by thymoxamine. These results show the possibility that the protective effect of thymoxamine on the manifestation of VA may be mainly associated with inhibitions of pressor effects mediated through vascular alpha-adrenoceptors.","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"東北ジャーナル刊行会"}]},"item_3_relation_28":{"attribute_name":"出版社DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1620/tjem.137.361","subitem_relation_type_select":"DOI"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"東北ジャーナル刊行会"},{"subitem_rights":"本文データは学協会の許諾に基づきJournal Archiveから複製したものである"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00408727","subitem_source_identifier_type":"ISSN"}]},"item_3_source_id_20":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"13493329","subitem_source_identifier_type":"ISSN"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Oguro, Katsunori"}]},{"creatorNames":[{"creatorName":"Hashimoto, Hisakuni"}]},{"creatorNames":[{"creatorName":"Nakashima, Mitsuyoshi"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-08-27"}],"displaytype":"detail","filename":"Tohoku Journal-137-361.pdf","filesize":[{"value":"734.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Tohoku Journal-137-361.pdf","url":"https://hama-med.repo.nii.ac.jp/record/2425/files/Tohoku Journal-137-361.pdf"},"version_id":"7ecfc854-ef15-43aa-b41b-bea53acd78c9"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"alpha blocker","subitem_subject_scheme":"Other"},{"subitem_subject":"thymoxamine","subitem_subject_scheme":"Other"},{"subitem_subject":"phentolamine","subitem_subject_scheme":"Other"},{"subitem_subject":"ouabain-induced arrhythmias","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effects of Thymoxamine in Ouabain-Induced Arrhythmias in Dogs","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of Thymoxamine in Ouabain-Induced Arrhythmias in Dogs","subitem_title_language":"en"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-08-27"},"publish_date":"2013-08-27","publish_status":"0","recid":"2425","relation_version_is_last":true,"title":["Effects of Thymoxamine in Ouabain-Induced Arrhythmias in Dogs"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-08-02T05:04:40.227943+00:00"}