{"created":"2023-06-20T15:47:54.565652+00:00","id":2427,"links":{},"metadata":{"_buckets":{"deposit":"28ef7d67-3e29-4220-bbf2-96f7f1ed7ace"},"_deposit":{"created_by":4,"id":"2427","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"2427"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00002427","sets":["1:11"]},"author_link":[],"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1992-03-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"352","bibliographicPageStart":"344","bibliographicVolumeNumber":"57","bibliographic_titles":[{"bibliographic_title":"Japanese Circulation Journal"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To clarify the role of phospholipase C (PLC) in arrythmias and cell injury during myocardial ischemia/reperfusion, we studied its effects on electrophysiology and [Ca2+]i in guinea pig hearts. After exposure to PLC (1 and 2 U/ml), the action potential durations of right ventricular papillary muscles were decreased. Delayed afterdepolarizations were observed in all of the preparations, and some developed into triggered activities. Developed tension decreased after an initial increase for the first 5 min, while resting tension increased consistently. The effects of PLC (0.02, 0.1, and 0.2 U/ml) on [Ca2+]i of ventricular myocytes were measured using fura-2 fluorescence. The ratio of rod-shaped cells to all cells decreased in a time- and a concentration-dependent manner. Perfusion with 0.1 U/ml PLC elevated [Ca2+]i from 56±5 nM to 245 ±47 nM before cell rounding, and to 1167±172 nM after cell rounding, suggesting that PLC causes Ca2+ overload. In conclusion, activation of PLC may play a role in arrhythmias and cell injury during ischemia/reperfusion. The increase in [Ca2+]i during ischemia/reperfusion may activate phospholipase, which would further increase [Ca2+]i to form a vicious cycle.","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本循環器学会"}]},"item_3_relation_28":{"attribute_name":"出版社DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1253/jcj.57.344","subitem_relation_type_select":"DOI"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright日本循環器学会"},{"subitem_rights":"本文データは学協会の許諾に基づきJournal Archiveから複製したものである"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00471828","subitem_source_identifier_type":"ISSN"}]},"item_3_source_id_20":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"13474839","subitem_source_identifier_type":"ISSN"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hayashi, Hideharu"}]},{"creatorNames":[{"creatorName":"Miyata, Haruo"}]},{"creatorNames":[{"creatorName":"Terada, Hajime"}]},{"creatorNames":[{"creatorName":"Noda, Naohisa"}]},{"creatorNames":[{"creatorName":"Satoh, Hiroshi"}]},{"creatorNames":[{"creatorName":"Kobayashi, Akira"}]},{"creatorNames":[{"creatorName":"Yamazaki, Noboru"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-08-27"}],"displaytype":"detail","filename":"JCircJ-57-344.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JCircJ-57-344.pdf","url":"https://hama-med.repo.nii.ac.jp/record/2427/files/JCircJ-57-344.pdf"},"version_id":"30ef1b8f-ec8b-4c8d-8395-e7d64960849e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Phospholipase C","subitem_subject_scheme":"Other"},{"subitem_subject":"Fura-2","subitem_subject_scheme":"Other"},{"subitem_subject":"Intracellular Ca2+ concentration","subitem_subject_scheme":"Other"},{"subitem_subject":"Delayed afterdepolarization","subitem_subject_scheme":"Other"},{"subitem_subject":"Ca2+ overload","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"EFFECTS OF PHOSPHOLIPASE C ON ACTION POTENTIALS AND INTRACELLULAR Ca2+ CONCENTRATION IN GUINEA PIG HEART","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"EFFECTS OF PHOSPHOLIPASE C ON ACTION POTENTIALS AND INTRACELLULAR Ca2+ CONCENTRATION IN GUINEA PIG HEART","subitem_title_language":"en"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-08-27"},"publish_date":"2013-08-27","publish_status":"0","recid":"2427","relation_version_is_last":true,"title":["EFFECTS OF PHOSPHOLIPASE C ON ACTION POTENTIALS AND INTRACELLULAR Ca2+ CONCENTRATION IN GUINEA PIG HEART"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-08-02T05:04:44.079649+00:00"}