{"created":"2023-06-20T15:47:54.637134+00:00","id":2428,"links":{},"metadata":{"_buckets":{"deposit":"e9b072e4-7da6-442b-bbd9-fe8e6059a023"},"_deposit":{"created_by":4,"id":"2428","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"2428"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00002428","sets":["1:11"]},"author_link":[],"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1992-05-22","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"457","bibliographicPageStart":"449","bibliographicVolumeNumber":"57","bibliographic_titles":[{"bibliographic_title":"Japanese Circulation Journal"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To investigate the role of abnormal Ca2+ metabolism in the diminished contractile function of diabetic myocardium, we measured the Ca2+ transients and cell contraction of diabetic rat myocytes. Isolated diabetic (8 weeks after 40 mg/kg streptozotocin, i.v.) and normal myocytes were loaded with acetoxymethyl ester of indo-1 (indo-1/AM). Ca2+ transients and cell circumferential shortening were measured simultaneously, using high temporal resolution video image analysis. The diastolic base and systolic peak of Ca2+ transients were significantly lower in diabetic myocytes than in normal myocytes (peak ratios: 0.49±0.02 vs 0.56±0.01, p<0.05; base ratios: 0.43±0.01 vs 0.48±0.01, p<0.01, Mea±SE). The cell circumferential shortening of diabetic myocytes was also significantly lower than that of normal myocytes (2.9±0.3% vs 5.2±0.9%, p<0.05). Although isoproterenol (10-8 and 10-7 M) increased the peak of Ca2+ transients in both diabetic and normal myocytes, the peak value of Ca2+ transients in the diabetic group was significantly lower than that in the normal group. The decreased Ca2+ transients may be responsible for the decreased contractile function in diabetic myocardium","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本循環器学会"}]},"item_3_relation_28":{"attribute_name":"出版社DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1253/jcj.57.449","subitem_relation_type_select":"DOI"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright日本循環器学会"},{"subitem_rights":"本文データは学協会の許諾に基づきJournal Archiveから複製したものである"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00471828","subitem_source_identifier_type":"ISSN"}]},"item_3_source_id_20":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"13474839","subitem_source_identifier_type":"ISSN"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Noda, Naohisa"}]},{"creatorNames":[{"creatorName":"Hayashi, Hideharu"}]},{"creatorNames":[{"creatorName":"Satoh, Hiroshi"}]},{"creatorNames":[{"creatorName":"Terada, hajime"}]},{"creatorNames":[{"creatorName":"Hirano, Masahiko"}]},{"creatorNames":[{"creatorName":"Kobayashi, Akira"}]},{"creatorNames":[{"creatorName":"Yamazaki, Noboru"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-08-27"}],"displaytype":"detail","filename":"JCircJ-157-449.pdf","filesize":[{"value":"1.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JCircJ-157-449.pdf","url":"https://hama-med.repo.nii.ac.jp/record/2428/files/JCircJ-157-449.pdf"},"version_id":"523850a0-43c9-4fc5-8b5d-e8b23df3463d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Indo-1","subitem_subject_scheme":"Other"},{"subitem_subject":"〔Ca2+〕i","subitem_subject_scheme":"Other"},{"subitem_subject":"Cell contraction","subitem_subject_scheme":"Other"},{"subitem_subject":"Isoproterenol","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Ca2+ TRANSIENTS AND CELL SHORTENING IN DIABETIC RAT VENTRICULAR MYOCYTES","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Ca2+ TRANSIENTS AND CELL SHORTENING IN DIABETIC RAT VENTRICULAR MYOCYTES","subitem_title_language":"en"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-08-27"},"publish_date":"2013-08-27","publish_status":"0","recid":"2428","relation_version_is_last":true,"title":["Ca2+ TRANSIENTS AND CELL SHORTENING IN DIABETIC RAT VENTRICULAR MYOCYTES"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-08-02T05:04:45.741922+00:00"}