{"created":"2023-06-20T15:47:55.219392+00:00","id":2436,"links":{},"metadata":{"_buckets":{"deposit":"995214e8-73fe-4b2e-bc55-f770d2be2be7"},"_deposit":{"created_by":4,"id":"2436","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"2436"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00002436","sets":["1:11"]},"author_link":[],"item_3_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"The 53th Annual Scientific Session of the Japanese Circulation Society"}]},"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1989-07-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"661","bibliographicPageStart":"653","bibliographicVolumeNumber":"54","bibliographic_titles":[{"bibliographic_title":"Japanese Circulation Journal"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Automaticities due to delayed afterdepolarizations. elicited upon reoxygenation, are thought to be caused by Ca overload. Since tissue Ca uptake upon reoxygenation has been reported to be closely related to metabolic inhibition during hypoxic perfusion. the relationship between the degree of metabolic inhibition during hypoxia and reoxygenation-induced arrhythmias was investigated in guinea pig papillary muscles. (1) Arrhythmias occurred after 60 min substrate-free hypoxia. but not after 30 min hypoxia. The chance of automaticities was closely related with the increase in resting tention achieved during hypoxic period. The incidence of arrhythmias was. however. lower after 90 or 120 min hypoxia. (2) There were arrhythmias after 20-30 min hypoxia with glycolytic inhibition (20 mM 2-deoxyglucose + 5 mM acetate). On the other hand. 60-min hypoxia in the presence of 5 mM glucose did not elicit arrhythmias on reoxygenation. (3) Stimulation of glycolysis (50 mM glucose) during substrate-free hypoxia prolonged the action potential duration. but did not cause arrhythmias. Washout of cyanide (1 mM) after 60 min perfusion in the presence of oxygen, caused arrhythmias and aftercontractions. These results suggest that the degree of metabolic inhibition during hypoxia is closely related to Ca overload and the resultant arrhythmias upon reoxygena-tion. The release of inhibited oxidative phosphoryiation, rather than the reintroduction of oxygen per se, was thought to be the key mechanism of reoxygenation-induced arrhythmias.","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本循環器学会"}]},"item_3_relation_28":{"attribute_name":"出版社DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1253/jcj.54.653","subitem_relation_type_select":"DOI"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright日本循環器学会"},{"subitem_rights":"本文データは学協会の許諾に基づきJournal Archiveから複製したものである"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00471828","subitem_source_identifier_type":"ISSN"}]},"item_3_source_id_20":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"13474839","subitem_source_identifier_type":"ISSN"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hayashi, Hideharu"}]},{"creatorNames":[{"creatorName":"Terada, Hajime"}]},{"creatorNames":[{"creatorName":"Kobayashi, Akira"}]},{"creatorNames":[{"creatorName":"Yamazaki, Noboru"}]},{"creatorNames":[{"creatorName":"Terence, F. Mcdonald"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-08-27"}],"displaytype":"detail","filename":"JCircJ-54-653.pdf","filesize":[{"value":"963.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JCircJ-54-653.pdf","url":"https://hama-med.repo.nii.ac.jp/record/2436/files/JCircJ-54-653.pdf"},"version_id":"c125ebfa-bbb0-4f92-a26b-f161a2832b2b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Delayed afterdepolarization","subitem_subject_scheme":"Other"},{"subitem_subject":"Triggered activity","subitem_subject_scheme":"Other"},{"subitem_subject":"Ca2+overload","subitem_subject_scheme":"Other"},{"subitem_subject":"Sodium cyanide","subitem_subject_scheme":"Other"},{"subitem_subject":"Oxidative phosphorylation","subitem_subject_scheme":"Other"},{"subitem_subject":"After comtroction","subitem_subject_scheme":"Other"},{"subitem_subject":"Reoxygenation","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ARRHYTHMIA AFTER THE RELEASE OF INHIBITED OXIDATIVE PHOSPHORYLATION","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ARRHYTHMIA AFTER THE RELEASE OF INHIBITED OXIDATIVE PHOSPHORYLATION","subitem_title_language":"en"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-08-27"},"publish_date":"2013-08-27","publish_status":"0","recid":"2436","relation_version_is_last":true,"title":["ARRHYTHMIA AFTER THE RELEASE OF INHIBITED OXIDATIVE PHOSPHORYLATION"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-08-02T05:05:04.883039+00:00"}