{"created":"2023-06-20T15:47:55.507578+00:00","id":2440,"links":{},"metadata":{"_buckets":{"deposit":"22073542-cc6b-40f5-9535-6cc21ce31fae"},"_deposit":{"created_by":4,"id":"2440","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"2440"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00002440","sets":["1:11"]},"author_link":[],"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1992-04-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"532","bibliographicPageStart":"521","bibliographicVolumeNumber":"57","bibliographic_titles":[{"bibliographic_title":"Japanese Circulation Journal"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The relationships between pressure rate product (PRP) and flux (PCr→ATP) or flux (Pi→ATP) were studied in isolated perfused rat hearts by the saturation transfer method using 31P-NMR. The effects of propranolol and diltiazem on phosphate metabolism were also studied. After a 40 min preischemic period, the hearts were subjected to a 15 min period of ischemia, followed by 60 min of reperfusion. Propranolol (0.4-1.2μM) or diltiazem (3.0-6.0μM) was infused for 30 min before ischemia and reinfused after reperfusion for 60 min. The flux (PCr→ATP)/PRP ratio at reperfusion did not differ from that at preischemia. This value was also not affected by propranolol or diltiazem treatment. However, the flux (Pi→ATP)/PRP ratio at reperfusion was significantly less than that at preischemia. Moreover, this value was significantly improved by propranolol or diltiazem treatment. This study demonstrates that 1) flux (PCr→ATP) has a good correlation with cardiac performance, 2) stunned myocardium needs less ATP turnover for survival of its depressed contractile activity, and 3) flux (Pi→ATP) can limit recovery of postischemic performance. Protective effects of propranolol and diltiazem are exerted on the flux (Pi-ATP), i.e. ATP derived from glycolytic flux, in the reperfused heart.","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本循環器学会"}]},"item_3_relation_28":{"attribute_name":"出版社DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1253/jcj.57.521","subitem_relation_type_select":"DOI"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright日本循環器学会"},{"subitem_rights":"本文データは学協会の許諾に基づきJournal Archiveから複製したものである"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00471828","subitem_source_identifier_type":"ISSN"}]},"item_3_source_id_20":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"13474839","subitem_source_identifier_type":"ISSN"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Okayama, Yoshimi"}]},{"creatorNames":[{"creatorName":"Kobayashi, Akira"}]},{"creatorNames":[{"creatorName":"Fujise, Yutaka"}]},{"creatorNames":[{"creatorName":"Yamazaki, Noboru"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-08-27"}],"displaytype":"detail","filename":"JCircJ-57-521.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JCircJ-57-521.pdf","url":"https://hama-med.repo.nii.ac.jp/record/2440/files/JCircJ-57-521.pdf"},"version_id":"444a8fa8-d36b-471e-80d8-d989631417de"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Saturation transfer","subitem_subject_scheme":"Other"},{"subitem_subject":"Reperfused heart","subitem_subject_scheme":"Other"},{"subitem_subject":"Propranolol","subitem_subject_scheme":"Other"},{"subitem_subject":"Diltiazem","subitem_subject_scheme":"Other"},{"subitem_subject":"31P-NMR","subitem_subject_scheme":"Other"},{"subitem_subject":"High-energy phosphate","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"EFFECTS OF PROPRANOLOL AND DILTIAZEM ON THE RATE OF HIGH-ENERGY PHOSPHATE METABOLISM IN REPERFUSED RAT HEARTS","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"EFFECTS OF PROPRANOLOL AND DILTIAZEM ON THE RATE OF HIGH-ENERGY PHOSPHATE METABOLISM IN REPERFUSED RAT HEARTS","subitem_title_language":"en"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-08-27"},"publish_date":"2013-08-27","publish_status":"0","recid":"2440","relation_version_is_last":true,"title":["EFFECTS OF PROPRANOLOL AND DILTIAZEM ON THE RATE OF HIGH-ENERGY PHOSPHATE METABOLISM IN REPERFUSED RAT HEARTS"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-08-02T05:05:14.485409+00:00"}