{"created":"2023-06-20T15:48:06.908908+00:00","id":2639,"links":{},"metadata":{"_buckets":{"deposit":"2a2941a6-0c89-4ce8-9e8f-97564345a30c"},"_deposit":{"created_by":4,"id":"2639","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"2639"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00002639","sets":["2:15:17"]},"author_link":["7770"],"control_number":"2639","item_5_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"放射性ヨウ素標識キナゾリン誘導体は非小細胞肺癌において放射線感受性を予測しうる","subitem_alternative_title_language":"ja"}]},"item_5_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-09-20","bibliographicIssueDateType":"Issued"}}]},"item_5_date_granted_17":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2013-09-20"}]},"item_5_degree_grantor_15":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"浜松医科大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"13802","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_12":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_5_description_10":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"雑誌掲載タイトル：Relationship between uptake of a radioiodinated quinazoline derivative and radiosensitivity in non-small cell lung cancer\n雑誌名：American Journal of Nuclear Medicine and Molecular Imaging\n巻号：Volume 4, No.4 : p293-384, 2014","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_13":{"attribute_name":"学位の区分","attribute_value_mlt":[{"subitem_description":"doctoral","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_description_14":{"attribute_name":"学位の分野","attribute_value_mlt":[{"subitem_description":"医学系研究科","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective\nThe aim of this study was to determine whether the uptake of radioiodinated 6-(3-morpholinopropoxy)-7-ethoxy-4-(3′-iodophenoxy) quinazoline ([125I]PYK) can predict the response to radiotherapy of NSCLC cells in vitro.\nMethods\nFour NSCLC cell lines PC9, HCC827, A549 and H1975 were used. The cells were irradiated with doses ranging from 2 Gy to 8 Gy and/or exposed to 1 μM gefitinib. The effects of radiation and gefitinib were assessed by CCK-8 assay. The uptake of [125I]PYK was determined by incubating cells with the tracer. Cell cycle and EGFR expression were assessed by flow cytometry.\nResults\nThe uptake of [125I]PYK in PC9 and HCC827 cells was higher than in A549 and H1975 cells. PC9 cells and HCC827 cells were more radiosensitive than A549 and H1975 cells. Gefitinib pretreatment reduced S phase fraction and enhanced radiation effect in PC9 and HCC827 cells.\nConclusion\nThe uptake of [125I]PYK related to the effect of radiation in NSCLC cells. The results suggested that radioiodinated PYK might be useful in predicting the response of NSCLC in patients to radiotherapy.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_5_dissertation_number_18":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第659号"}]},"item_5_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Zhu, Huijun","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7770","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-08-27"}],"displaytype":"detail","filename":"DT_659ronbun.pdf","filesize":[{"value":"374 KB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"論文本文","objectType":"fulltext","url":"https://hama-med.repo.nii.ac.jp/record/2639/files/DT_659ronbun.pdf"},"version_id":"375909cb-585e-49d9-90c1-5cc9041fc086"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"[125I]PYK","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"irradiation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"gefitinib","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"EGFR","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"NSCLC","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"A radioiodinated quinazolin derivative can predict radiosensitivity in non-small cell lung cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A radioiodinated quinazolin derivative can predict radiosensitivity in non-small cell lung cancer","subitem_title_language":"en"}]},"item_type_id":"5","owner":"4","path":["17"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2015-10-06"},"publish_date":"2015-10-06","publish_status":"0","recid":"2639","relation_version_is_last":true,"title":["A radioiodinated quinazolin derivative can predict radiosensitivity in non-small cell lung cancer"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-10-23T04:06:05.196878+00:00"}