{"created":"2023-06-20T15:48:07.921321+00:00","id":2654,"links":{},"metadata":{"_buckets":{"deposit":"5c215a20-8535-4645-bda2-6f1fbf824013"},"_deposit":{"created_by":4,"id":"2654","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"2654"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00002654","sets":["2:15:17"]},"author_link":["7785"],"item_5_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"腎癌における性別の影響: 全生存期間に及ぼすFABP7 とBRN2 発現の関係","subitem_alternative_title_language":"ja"}]},"item_5_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{"bibliographic_title":"Clinical Medicine Insights: Oncology","bibliographic_titleLang":"en"}]}]},"item_5_date_granted_17":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2014-03-17"}]},"item_5_degree_grantor_15":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"浜松医科大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"13802","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_12":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_5_description_13":{"attribute_name":"学位の区分","attribute_value_mlt":[{"subitem_description":"doctoral","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_description_14":{"attribute_name":"学位の分野","attribute_value_mlt":[{"subitem_description":"医学系研究科","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective: To investigate the relationship between gender differences in fatty acid-binding protein7 (FABP7) and BRN2 (POU class 3 homeobox 2) expression in renal cell carcinoma (RCC) and the prognosis of patients with RCC.\nMaterials and Methods: immunohistochemical (IHC) staining as well as reverse transcription-polymerase chain reaction (RT-PCR) was performed in renal tissues from 103 patients (83 men, mean age=63.6 years old; 20 women, mean age=63.1 years old) underwent radical nephrectomy from January 1, 2001 through December 31, 2010. The probability of overall patient survival was estimated using the Kaplan-Meier method.\nResults: FABP7 mRNA expression was more frequent in men (P=0.07) while BRN2 protein expression was significantly more frequent in women (P=0.029). In particular, FABP7 was expressed in 100% of G1 renal cell carcinoma both in mRNA and protein levels. In women, FABP7 (-) and BRN2 (+) groups had a worse prognosis both in mRNA level (P=0.038) and protein level (P=0.058). BRN2 was expressed 100% of papillary RCC both in mRNA and protein levels.\nConclusions: Our results demonstrated that gender was a key factor in FABP7 and BRN2 expression in RCC, and the combination with FABP7 and BRN2 stratified by gender could be a new potential prognostic factor in patients with RCC.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_5_dissertation_number_18":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第682号"}]},"item_5_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"SAGE Publications","subitem_publisher_language":"en"}]},"item_5_relation_26":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"24653654","subitem_relation_type_select":"PMID"}}]},"item_5_relation_28":{"attribute_name":"出版社DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.4137/CMO.S13684","subitem_relation_type_select":"DOI"}}]},"item_5_source_id_20":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"1179-5549","subitem_source_identifier_type":"EISSN"}]},"item_5_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tan, Cheng","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"7785","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-08-27"}],"displaytype":"detail","filename":"DT_682ronbun.pdf","filesize":[{"value":"947.0 kB"}],"format":"application/pdf","licensetype":"license_3","mimetype":"application/pdf","url":{"label":"論文本文","objectType":"fulltext","url":"https://hama-med.repo.nii.ac.jp/record/2654/files/DT_682ronbun.pdf"},"version_id":"6eccf372-ecd0-456a-bd3e-1305dc63f426"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"BRN2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"FABP7","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"gender","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"overall survival","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"renal cell carcinoma","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Impact of gender in renal cell carcinoma: the relationship of FABP7 and BRN2 expression with overall survival","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Impact of gender in renal cell carcinoma: the relationship of FABP7 and BRN2 expression with overall survival","subitem_title_language":"en"}]},"item_type_id":"5","owner":"4","path":["17"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2015-01-09"},"publish_date":"2015-01-09","publish_status":"0","recid":"2654","relation_version_is_last":true,"title":["Impact of gender in renal cell carcinoma: the relationship of FABP7 and BRN2 expression with overall survival"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-10-23T06:11:52.963223+00:00"}