{"created":"2023-06-20T15:48:14.857113+00:00","id":2765,"links":{},"metadata":{"_buckets":{"deposit":"16df778f-4965-47b8-9f8a-e8b69f206734"},"_deposit":{"created_by":4,"id":"2765","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"2765"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00002765","sets":["2:15:17"]},"author_link":["8147"],"item_5_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"活動中の騒音曝露と生体ラット脳内での神経新生 : 予備的検討","subitem_alternative_title_language":"ja"}]},"item_5_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{"bibliographic_title":"Journal of Neurology & Neurophysiology","bibliographic_titleLang":"en"}]}]},"item_5_date_granted_17":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2015-03-16"}]},"item_5_degree_grantor_15":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"浜松医科大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"13802","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_12":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_5_description_13":{"attribute_name":"学位の区分","attribute_value_mlt":[{"subitem_description":"doctoral","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_description_14":{"attribute_name":"学位の分野","attribute_value_mlt":[{"subitem_description":"医学系研究科","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective: The effects of loud noise (80 dB) on neurogenesis in the subventricular zone (SVZ) and the hippocampal subgranular zone (SGZ) was investigated in vivo in the rat brain using positron emission tomography (PET) with 3’-deoxy-3’-[18F]fluoro-L-thymidine ([18F]FLT), a marker for thymidine kinase I (TK-1) related to cell proliferation and for neurogenesis in SVZ and SGZ.\nMethods: Five young Sprague-Dawley rats were exposed to loud noise from two speakers set in front of their cages during the night for 4 nights, and 5 control rats were exposed to normal quiet conditions. PET was performed 4 days after the exposure.\nResults: The accumulation of [18F]FLT in SVZ was significantly lower in the rats with noise exposure than in the control rats. The level of [18F]FLT uptake was lower in the SVZ than in the SGZ.\nConclusion: Our results indicate that loud noise exposure during the awake period may be related to the decrease in proliferative capacity of neural stem cells especially in the SVZ of the living rat brain. This finding may indicate that persistent loud noise during daily life is harmful to brain development in humans.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_5_dissertation_number_18":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第696号"}]},"item_5_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"OMICS International","subitem_publisher_language":"en"}]},"item_5_relation_28":{"attribute_name":"出版社DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.4172/2155-9562","subitem_relation_type_select":"DOI"}}]},"item_5_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2155-9562","subitem_source_identifier_type":"PISSN"}]},"item_5_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shimizu, Yoshiyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8147","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-08-27"}],"displaytype":"detail","filename":"DT_696ronbun.pdf","filesize":[{"value":"318.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"論文本文","objectType":"fulltext","url":"https://hama-med.repo.nii.ac.jp/record/2765/files/DT_696ronbun.pdf"},"version_id":"0443fe6d-72c6-417a-aff1-e899fcd1cd94"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Neurogenesis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Noise","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Rat","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"[18F]FLT","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Positron emission tomography","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"subventricular zone","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hippocampal subgranular zone","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Loud noise exposure during activity and neurogenesis in the living rat brain: A preliminary study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Loud noise exposure during activity and neurogenesis in the living rat brain: A preliminary study","subitem_title_language":"en"}]},"item_type_id":"5","owner":"4","path":["17"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2015-11-20"},"publish_date":"2015-11-20","publish_status":"0","recid":"2765","relation_version_is_last":true,"title":["Loud noise exposure during activity and neurogenesis in the living rat brain: A preliminary study"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-10-20T04:31:13.729600+00:00"}