{"created":"2023-06-20T15:48:22.552088+00:00","id":2894,"links":{},"metadata":{"_buckets":{"deposit":"b93a9e44-e14e-44c5-be24-f3ad6f96c17c"},"_deposit":{"created_by":4,"id":"2894","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"2894"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00002894","sets":["2:15:17"]},"author_link":["8620"],"item_5_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"加齢における認知処理過程での課題遂行前の前頭前野の賦活：近赤外分光法による検討","subitem_alternative_title_language":"ja"}]},"item_5_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-06-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageStart":"e98779","bibliographicVolumeNumber":"9","bibliographic_titles":[{"bibliographic_title":"PLoS ONE","bibliographic_titleLang":"en"}]}]},"item_5_date_granted_17":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2015-09-18"}]},"item_5_degree_grantor_15":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"浜松医科大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"13802","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_12":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_5_description_13":{"attribute_name":"学位の区分","attribute_value_mlt":[{"subitem_description":"doctoral","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_description_14":{"attribute_name":"学位の分野","attribute_value_mlt":[{"subitem_description":"医学系研究科","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: Cognitive processing generally deteriorates as people age. Recent neuroimaging studies have shown that the prefrontal cortex (PFC) is involved in human-specific behavior, such as preparing for future actions and prospective memory; hence, the PFC may be voluntarily activated even during the ‘‘resting’’ condition that precedes task execution. The purpose of the present study was to investigate changes in voluntary pre-task activation as a result of aging using a paradigm that includes a longer intertrial interval (e.g., 30 sec) than has been used in previous studies.\nMethods: A total of 120 cognitively normal adults (young: 60, old: 60) participated in this near-infrared spectroscopy (NIRS) study. All subjects performed 6 repetitions of the working memory task, which included a 30 sec resting period and a 28.8 sec task period. The resting period was divided into baseline and pre-task (preT) periods, and the task period was divided into early easy task (eT) and late difficult task (dT) periods. We then normalized the data, analyzed the magnitude of task-related NIRS responses in each period and compared the results between groups using an analysis of variance test.\nResults: Statistical analyses revealed a significant interaction between group × optode location × period, in which hemodynamic responses in the PFC during the preT period were smaller in the elderly in than young adults. By contrast, during the task period, the hemodynamic responses were higher in the lateral PFC in the elderly than in young adults. Spearman’s rank correlation analysis showed a positive correlation between hemodynamic changes during the preT period in the PFC and correct answer ratios in both groups.\nConclusions: These findings suggest that more pre-task activation in the anterior PFC is related to better cognitive performance in humans. Thus, a reduction in this activation might partly explain cognitive decline in the elderly.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_5_dissertation_number_18":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第707号"}]},"item_5_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"PLOS (Public Library of Science)","subitem_publisher_language":"en"}]},"item_5_relation_26":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"24897305","subitem_relation_type_select":"PMID"}}]},"item_5_relation_28":{"attribute_name":"出版社DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1371/journal.pone.0098779","subitem_relation_type_select":"DOI"}}]},"item_5_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright: 2014 Oboshi et al.","subitem_rights_language":"en"}]},"item_5_source_id_20":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"1932-6203","subitem_source_identifier_type":"EISSN"}]},"item_5_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Oboshi, Yumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"8620","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-08-27"}],"displaytype":"detail","filename":"DT_707ronbun.pdf","filesize":[{"value":"3.0 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"label":"論文本文","objectType":"fulltext","url":"https://hama-med.repo.nii.ac.jp/record/2894/files/DT_707ronbun.pdf"},"version_id":"0e447207-e64f-4c91-b0e3-9e79ed1cc975"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Pre-task prefrontal activation during cognitive processes in aging: a near-infrared spectroscopy study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Pre-task prefrontal activation during cognitive processes in aging: a near-infrared spectroscopy study","subitem_title_language":"en"}]},"item_type_id":"5","owner":"4","path":["17"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2016-06-02"},"publish_date":"2016-06-02","publish_status":"0","recid":"2894","relation_version_is_last":true,"title":["Pre-task prefrontal activation during cognitive processes in aging: a near-infrared spectroscopy study"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-10-20T04:31:25.629502+00:00"}