{"created":"2023-06-20T15:48:32.301487+00:00","id":3058,"links":{},"metadata":{"_buckets":{"deposit":"7d0704a6-c5d8-4e32-acc6-b0a11d3e08b8"},"_deposit":{"created_by":4,"id":"3058","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"3058"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00003058","sets":["2:15:17"]},"author_link":["9043"],"item_5_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"BMPシグナル関連タンパク質は成体小脳において多様性を持って発現している","subitem_alternative_title_language":"ja"}]},"item_5_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"83","bibliographicPageStart":"70","bibliographicVolumeNumber":"46","bibliographic_titles":[{"bibliographic_title":"Journal of Brain Science","bibliographic_titleLang":"en"}]}]},"item_5_date_granted_17":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2016-09-16"}]},"item_5_degree_grantor_15":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"浜松医科大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"13802","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_5_degree_name_12":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_5_description_13":{"attribute_name":"学位の区分","attribute_value_mlt":[{"subitem_description":"doctoral","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_5_description_14":{"attribute_name":"学位の分野","attribute_value_mlt":[{"subitem_description":"医学系研究科","subitem_description_language":"ja","subitem_description_type":"Other"}]},"item_5_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We investigated the distributions of BMP ligands (BMP2, BMP4, BMP5), BMP receptors (BMPR) (BMPRIA, BMPR IB, BMPR II ), BMP antagonists (chordin and noggin) in the adult rat cerebellum. They are differentially expressed throughout the cerebellum. Interestingly, they are more abundantly expressed in the molecular cell layer, where neuronal plastic phenomena, such as long-term depression (LTD) and rebound potentiation (RP) are observed, than in the granule cell layer. In addition, neurons in the cerebellar nuclei also express all of them. We also found differential usages of BMPRIA and BMPRIB in the cerebellum. For example, in the molecular layer, BMPRIA is mainly expressed in the processes of Bergmann glia, while BMPRIB is mainly detected in the dendrites of Purkinje cells. In addition, BMPRIB is expressed in both cell bodies and dendrites of Purkinje cells, while BMPRIA is mainly expressed in cell bodies of Purkinje cells, showing that BMPRIA and BMPRIB are differentially targeted in a Purkinje cell. These data strongly indicate that differential BMP signaling should be needed to keep the proper function of the cerebellum in the adult rat cerebellum.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_5_dissertation_number_18":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第736号"}]},"item_5_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本脳科学会","subitem_publisher_language":"ja"},{"subitem_publisher":"Japan Brain Science society","subitem_publisher_language":"en"}]},"item_5_relation_28":{"attribute_name":"出版社DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.20821/jbs.46.0_70","subitem_relation_type_select":"DOI"}}]},"item_5_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1341-5301","subitem_source_identifier_type":"PISSN"}]},"item_5_source_id_20":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"2432-2512","subitem_source_identifier_type":"EISSN"}]},"item_5_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kesavamoorthy, Gandhervin","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"9043","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-08-27"}],"displaytype":"detail","filename":"DT_736ronbun.pdf","filesize":[{"value":"4.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"論文本文","objectType":"fulltext","url":"https://hama-med.repo.nii.ac.jp/record/3058/files/DT_736ronbun.pdf"},"version_id":"e1f29cae-e0ed-4ccc-bde4-584dbe0ab1c2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"BMP","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"BMP receptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"chordin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"noggin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"immunohistochemistry","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"BMP signaling-related proteins are differentially expressed in the adult cerebellum","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"BMP signaling-related proteins are differentially expressed in the adult cerebellum","subitem_title_language":"en"}]},"item_type_id":"5","owner":"4","path":["17"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-08-24"},"publish_date":"2017-08-24","publish_status":"0","recid":"3058","relation_version_is_last":true,"title":["BMP signaling-related proteins are differentially expressed in the adult cerebellum"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-10-18T02:55:34.267055+00:00"}