@article{oai:hama-med.repo.nii.ac.jp:00003518,
 author = {古川, 琢麻 and 伊藤, 敏谷 and 安立, 匡志 and 田村, 直顕 and 望月, 琴美 and 向, 麻利 and 柴田, 俊章 and 村上, 浩雄 and 中山, 毅 and 内田, 季之 and 鈴木, 一有 and 伊東, 宏晃},
 issue = {2},
 journal = {静岡産科婦人科学会雑誌},
 month = {Sep},
 note = {悪性腹膜中皮腫の2例を経験した。1例目は下腹部痛、倦怠感を主訴に受診し、腹膜癌による癌性腹膜炎が疑われ、2例目は骨盤内腫瘤および腹水・胸水貯留を認め卵巣癌Ⅲ期以上が疑われ、それぞれ試験開腹手術を行い術後病理検査にて上皮型の悪性腹膜中皮腫と診断された。中皮腫の確定診断に伴いアスベスト暴露歴を確認したところ、両症例ともアスベスト暴露の可能性が示唆された。術後療法としてペメトレキセドとシスプラチンによる化学療法を行い、１例目は部分奏効、２例目は化学療法に抵抗性を示した。また、2例目は病期進行中にニボルマブを導入したがProgressive diseaseにて治療を終了した。腹膜悪性中皮腫は稀な疾患であり、術前の画像所見および細胞診にて診断することは困難であるが、腹膜癌や卵巣癌が疑われる症例においては、本疾患も鑑別疾患の一つになる可能性を念頭に置く必要があると考えられた。, We encountered two cases of malignant peritoneal mesothelioma. The first patient visited our department with chief complaints of lower abdominal pain and malaise, and suspicion of cancerous peritonitis due to peritoneal cancer. The second patient was suspected as having stage III or above ovarian cancer with a pelvic mass and ascites/pleural effusions. These patients underwent laparotomy and were diagnosed with epithelial peritoneal mesothelioma by postoperative pathological examination. Upon the definitive diagnosis of mesothelioma, a history of asbestos exposure was suspected in both cases. Chemotherapy with pemetrexed and cisplatin was performed as postoperative therapy. The first patient showed a partial response, while the second one was resistant to the chemotherapy. For the second patient, nivolumab was introduced due stage progression. However, the treatment was terminated because of progressive disease. Peritoneal malignant mesothelioma is a rare disease, which cannot be easily diagnosed by preoperative imaging or cytology. This disease should be considered in the differential diagnosis of patients suspected of having peritoneal or ovarian cancer.},
 pages = {158--165},
 title = {産婦人科で治療を行った悪性腹膜中皮腫の2例},
 volume = {8},
 year = {2019}
}