{"created":"2023-06-20T15:49:05.638346+00:00","id":3641,"links":{},"metadata":{"_buckets":{"deposit":"c1b57cd0-15d6-47d2-9ca0-fd42a7964bd6"},"_deposit":{"created_by":4,"id":"3641","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"3641"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00003641","sets":["1:11"]},"author_link":[],"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-05","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"54","bibliographicPageStart":"47","bibliographicVolumeNumber":"143","bibliographic_titles":[{"bibliographic_title":"Lung Cancer"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objectives: Conventional evaluation of anti-tumor activity on the basis of tumor size is inadequate for immune checkpoint inhibitors (ICIs). We therefore aimed to assess the usefulness of intravoxel incoherent motion magnetic resonance imaging (IVIM-MRI) for evaluation of the therapeutic efficacy of ICIs.\nMaterials and Methods: A chest IVIM-MRI was performed before and 2, 4, and 8 weeks after administration of ICIs in patients with advanced non-small-cell lung cancer. Apparent diffusion coefficient (ADC), skewness of ADC (ADCskew), kurtosis of ADC (ADCkurt), true diffusion coefficient (D), pseudodiffusion coefficient (D*), and perfusion fraction (f) were evaluated at each evaluation point and changes from the baseline (Δ).\nResults: Twenty patients were enrolled in this study. An increased ADC 8 weeks and decreased ADCkurt and ΔADCkurt 4 weeks after ICIs was associated with objective responses and longer progression-free survival (PFS). A decreased ΔADCskew at 4 weeks was associated with objective responses, disease control, and longer PFS and overall survival. There was no correlation between the efficacy of ICIs and D, D* and f. All of three patients who had pseudoprogression had decreased ΔADCskew at 4 weeks and two of them had decreased ΔADCkurt at 4 weeks. Inversely, all five patients who had progressive disease (PD) did not have increased ΔADCskew at 4 weeks and only one of them had decreased ΔADCkurt at 4 weeks.\nConclusions: Changes in histograms of ADC may be useful for predicting long-term efficacy and distinguishing between pseudoprogression and actual PD after ICIs.","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_3_relation_26":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"32203770","subitem_relation_type_select":"PMID"}}]},"item_3_relation_28":{"attribute_name":"出版社DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.lungcan.2020.03.013","subitem_relation_type_select":"DOI"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/."}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0169-5002","subitem_source_identifier_type":"ISSN"}]},"item_3_source_id_20":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"1872-8332","subitem_source_identifier_type":"ISSN"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Karayama, Masato"}]},{"creatorNames":[{"creatorName":"Yoshizawa, Nobuko"}]},{"creatorNames":[{"creatorName":"Sugiyama, Masataka"}]},{"creatorNames":[{"creatorName":"Mori, Kazutaka"}]},{"creatorNames":[{"creatorName":"Yasui, Hideki "}]},{"creatorNames":[{"creatorName":"Hozumi, Hironao"}]},{"creatorNames":[{"creatorName":"Suzuki, Yuzo"}]},{"creatorNames":[{"creatorName":"Furuhashi, Kazuki"}]},{"creatorNames":[{"creatorName":"Fujisawa, Tomoyuki"}]},{"creatorNames":[{"creatorName":"Enomoto, Noriyuki"}]},{"creatorNames":[{"creatorName":"Nakamura, Yutaro"}]},{"creatorNames":[{"creatorName":"Inui, Naoki"}]},{"creatorNames":[{"creatorName":"Goshima, Satoshi"}]},{"creatorNames":[{"creatorName":"Suda, Takafumi"}]},{"creatorNames":[{"creatorName":"Takehara, Yasuo"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-06-01"}],"displaytype":"detail","filename":"Lung Cancer-143-47.pdf","filesize":[{"value":"2.2 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"Lung Cancer-143-47.pdf ","url":"https://hama-med.repo.nii.ac.jp/record/3641/files/Lung Cancer-143-47.pdf"},"version_id":"90fc9753-109f-4b69-890e-a1d394bcb27e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"IVIM-MRI","subitem_subject_scheme":"Other"},{"subitem_subject":"immune therapy","subitem_subject_scheme":"Other"},{"subitem_subject":"anti-programmed death-1 therapy","subitem_subject_scheme":"Other"},{"subitem_subject":"anti-PD-1 therapy","subitem_subject_scheme":"Other"},{"subitem_subject":"pseudoprogression","subitem_subject_scheme":"Other"},{"subitem_subject":"atypical radiologic response","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Intravoxel incoherent motion magnetic resonance imaging for predicting the long-term efficacy of immune checkpoint inhibitors in patients with non-small-cell lung cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Intravoxel incoherent motion magnetic resonance imaging for predicting the long-term efficacy of immune checkpoint inhibitors in patients with non-small-cell lung cancer","subitem_title_language":"en"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-06-01"},"publish_date":"2021-06-01","publish_status":"0","recid":"3641","relation_version_is_last":true,"title":["Intravoxel incoherent motion magnetic resonance imaging for predicting the long-term efficacy of immune checkpoint inhibitors in patients with non-small-cell lung cancer"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-08-02T05:23:43.693594+00:00"}