{"created":"2023-06-20T15:49:09.275723+00:00","id":3715,"links":{},"metadata":{"_buckets":{"deposit":"9cc35efb-1c42-4231-836d-d31186027274"},"_deposit":{"created_by":4,"id":"3715","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"3715"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00003715","sets":["1:12:78"]},"author_link":["10889","10890","10891","10892","10893","10894","10895","10896"],"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"8","bibliographicPageStart":"2","bibliographicVolumeNumber":"10","bibliographic_titles":[{"bibliographic_title":"静岡産科婦人科学会雑誌","bibliographic_titleLang":"ja"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"抗Jra抗体は、高頻度抗原であるJra抗原に対する不規則抗体で、一般に胎児新生児溶血性疾患 (hemolytic disease of the fetus and newborn (HDFN)) を発症する可能性は低いとされている。今回、高力価抗Jra抗体の存在下で、重度の胎児貧血をきたした症例を経験した。症例は27歳の経産婦 (G2P1) で、妊娠17週の時点で既に抗Jra抗体価は512倍と高値を呈し、MCA-PSV (middle cerebral artery peak systolic velocity) も高値であった (1.60 MoM (multiples of the median)) 。慎重に経過を観察し、妊娠30週の時点で胎児の心不全兆候を認め子宮内胎児輸血を行った。輸血後、MCA-PSV値が再上昇したため、妊娠32週の時点で帝王切開術の施行に至った。児は1,677g男児で、Hb値は10.0g/dlであった。生後の評価で、網状赤血球産生指数 (RPI) は低値で、総ビリルビン値正常、単球貪食能も低値であったことから、胎児貧血の機序として溶血の関与は否定的であることが示唆された。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Anti-Jra antibody is a rare type of red cell alloimmunization associated with pregnancy, but it rarely induces hemolytic disease of the fetus and newborn (HDFN). We report a case of severe fetal anemia caused by high-titer anti-Jra antibody. The patient was 27 years old and multigravida (G2P1). The anti-Jra titer was x512 and the MCA-PSV (middle cerebral artery peak systolic velocity) was high (1.60 MoM (multiples of the median)) at the 17th gestational week. At the 30th gestational week, intrauterine fetal blood transfusion was carried out for deteriorating fetal heart function. Although blood transfusion was performed, an increasing MCA-PSV value and poor heart function were noted again at the 32th gestational week, leading to cesarean section. The neonate was a 1677g male with moderate anemia (Hb 10.0g/dl). The low reticulocyte production index (RPI), normal level of total bilirubin and low level of monocyte phagocytosis assay suggested that the fetal anemia was caused not by hemolysis but by other mechanism.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"静岡産科婦人科学会","subitem_publisher_language":"ja"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"21871914","subitem_source_identifier_type":"ISSN"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"古川, 琢麻","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"増井, 好穂","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"加茂, 亜希","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"河村, 隆一","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"西口, 富三","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"伊藤, 正一","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"荻山, 佳子","creatorNameLang":"ja"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"村越, 毅","creatorNameLang":"ja"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-04-09"}],"displaytype":"detail","filename":"jsog_10_1_2.pdf","filesize":[{"value":"638.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"jsog_10_1_9","url":"https://hama-med.repo.nii.ac.jp/record/3715/files/jsog_10_1_2.pdf"},"version_id":"be03ac12-6fe1-4f3f-b067-a742caefcded"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"anti-Jra antibody","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"red cell alloimmunization","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"MCA-PSV(middle cerebral artery peak systolic velocity)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"HDFN(hemolytic disease of the fetus and newborn)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"intrauterine fetal blood transfusion","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"胎児輸血に至った抗Jra抗体陽性妊娠の1例","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"胎児輸血に至った抗Jra抗体陽性妊娠の1例","subitem_title_language":"ja"},{"subitem_title":"Case report of anti-Jra antibody positive pregnancy carried out intrauterine fetal blood transfusion","subitem_title_language":"en"}]},"item_type_id":"3","owner":"4","path":["78"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-04-09"},"publish_date":"2021-04-09","publish_status":"0","recid":"3715","relation_version_is_last":true,"title":["胎児輸血に至った抗Jra抗体陽性妊娠の1例"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-08-01T06:59:19.594990+00:00"}