{"created":"2023-06-20T15:49:09.986233+00:00","id":3733,"links":{},"metadata":{"_buckets":{"deposit":"258dd7c8-12f7-4684-815f-74e5aca45499"},"_deposit":{"created_by":4,"id":"3733","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"3733"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00003733","sets":["1:11"]},"author_link":[],"item_3_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"S100A4 in IPF"}]},"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"749","bibliographicPageStart":"743","bibliographicVolumeNumber":"25","bibliographic_titles":[{"bibliographic_title":"Respirology"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background and objective: Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with a poor prognosis. There are no established serum biomarkers for predicting the outcomes of IPF. S100 calcium binding protein A4 (S100A4) is considered a marker of fibroblasts; however, its clinical application remains to be investigated. We evaluated the clinical relevance of S100A4 in IPF patients.\nMethods: Serum S100A4 levels in 95 consecutive IPF patients and 50 healthy controls (HCs) were measured using enzyme-linked immunosorbent assay. S100A4 expression in lung tissues was determined using immunohistochemistry/immunofluorescence and its association with disease progression (defined as deterioration in lung function or death) and mortality was assessed using Kaplan?Meier method and Cox hazards analysis.\nResults: Serum S100A4 levels were undetectable in all HCs but were detectable in 26 (27.3%) of the 95 IPF patients (P<0.01). Immunostaining of lung tissues from IPF patients showed aggregation of numerous S100A4-expressing cells around the fibroblastic foci and mature fibrotic regions. IPF patients with higher serum S100A4 levels had a significantly worse prognosis than those with low serum levels (2-year cumulative survival rate, 41.7% vs. 77.0%, respectively, P<0.01). On multivariate analyses, baseline serum S100A4 levels (per 10 ng/mL increase) were independently associated with higher disease progression rate (odds ratio 1.06, P=0.01) and higher mortality (hazard ratio 1.18, P=0.03).\nConclusions: S100A4 is a promising serum biomarker that may help predict disease progression/mortality. Our findings may help establish treatment strategies for IPF.","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"John Wiley and Sons "}]},"item_3_relation_26":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"31597225","subitem_relation_type_select":"PMID"}}]},"item_3_relation_28":{"attribute_name":"出版社DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1111/resp.13707","subitem_relation_type_select":"DOI"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"\"This is the peer reviewed version of the following article: \"\"Clinical significance of serum S100 calcium binding protein A4 in idiopathic pulmonary fibrosis, Respirology; 25(7): 743-749, 2020\"\", which has been published in final form at \"\"https://doi.org/10.1111/resp.13707\"\". This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.\""}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1323-7799","subitem_source_identifier_type":"ISSN"}]},"item_3_source_id_20":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"1440-1843","subitem_source_identifier_type":"ISSN"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Akiyama, Norimichi"}]},{"creatorNames":[{"creatorName":"Hozumi, Hironao"}]},{"creatorNames":[{"creatorName":"Isayama, Takuya"}]},{"creatorNames":[{"creatorName":"Okada, Jun"}]},{"creatorNames":[{"creatorName":"Sugiura, Katsunori"}]},{"creatorNames":[{"creatorName":"Yasui, Hideki"}]},{"creatorNames":[{"creatorName":"Suzuki, Yuzo"}]},{"creatorNames":[{"creatorName":"Kono, Masato"}]},{"creatorNames":[{"creatorName":"Karayama, Masato"}]},{"creatorNames":[{"creatorName":"Furuhashi, Kazuki"}]},{"creatorNames":[{"creatorName":"Enomoto, Noriyuki"}]},{"creatorNames":[{"creatorName":"Fujisawa, Tomoyuki"}]},{"creatorNames":[{"creatorName":"Inui, Naoki"}]},{"creatorNames":[{"creatorName":"Nakamura, Yutaro"}]},{"creatorNames":[{"creatorName":"Suda, Takafumi"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-01"}],"displaytype":"detail","filename":"Respirology-25-743.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Respirology-25-743.pdf","url":"https://hama-med.repo.nii.ac.jp/record/3733/files/Respirology-25-743.pdf"},"version_id":"647f53ab-97ae-4643-8427-75bea0932830"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Biomarker","subitem_subject_scheme":"Other"},{"subitem_subject":"fibroblast","subitem_subject_scheme":"Other"},{"subitem_subject":"idiopathic pulmonary fibrosis","subitem_subject_scheme":"Other"},{"subitem_subject":"S100A4","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Clinical significance of serum S100 calcium binding protein A4 in idiopathic pulmonary fibrosis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Clinical significance of serum S100 calcium binding protein A4 in idiopathic pulmonary fibrosis","subitem_title_language":"en"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-07-01"},"publish_date":"2021-07-01","publish_status":"0","recid":"3733","relation_version_is_last":true,"title":["Clinical significance of serum S100 calcium binding protein A4 in idiopathic pulmonary fibrosis"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-08-02T05:24:03.261494+00:00"}