{"created":"2023-06-20T15:49:10.170182+00:00","id":3736,"links":{},"metadata":{"_buckets":{"deposit":"ec98a01e-3a2a-4dab-a20a-eccb4e8970a8"},"_deposit":{"created_by":4,"id":"3736","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"3736"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00003736","sets":["1:11"]},"author_link":[],"item_3_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Predictors of AE in biopsy-proven IPF"}]},"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"184","bibliographicPageStart":"177","bibliographicVolumeNumber":"58","bibliographic_titles":[{"bibliographic_title":"Respiratory Investigation"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Acute exacerbation (AE) is a major cause of death in patients with idiopathic pulmonary fibrosis (IPF). Current evidence on AE-IPF was largely based on clinical, rather than pathological, analyses.\nMethods: We investigated AE incidence and its predictors using clinical, radiological, and pathological data of patients diagnosed with IPF by multi-disciplinary discussion.\nThis study, a secondary analysis of previous research, included 155 patients with IPF who underwent surgical lung biopsy (SLB). Cumulative AE incidence was evaluated by the Kaplan?Meier method.\nPredictors of AE-IPF were analyzed with a Fine-Gray subdistribution hazard model. Sub-analysis was performed using propensity score-matching analysis.\nResults: In this cohort, median age was 66 years and median percent-predicted forced vital capacity 82.8%. The cumulative AE incidence rates at 30-days and one-year post-SLB were 1.9% and 7.6%, respectively. On multivariable analysis, a lower percent-predicted diffusing capacity of the lung for carbon monoxide (%DLCO) (hazard ratio 0.98 per 1% increase, P=0.02) and fibroblastic foci (FF)-present (vs. absent; hazard ratio 3.01, P=0.04) were independently associated with higher incidence of AE. The propensity score-matching analysis with adjustment for age, gender, and %DLCO revealed that the cumulative AE incidence rate was significantly higher in the FF-present subgroup than in the FF-absent subgroup (1-year incidence rate, 10.5% vs. 0%, respectively; P=0.04 by Gray’s test).\nConclusions: FF and %DLCO were independent predictors of AE in patients with biopsy-proven IPF. FF may be associated with the pathogenesis of AE-IPF.","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_3_relation_26":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"32205147","subitem_relation_type_select":"PMID"}}]},"item_3_relation_28":{"attribute_name":"出版社DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.resinv.2020.02.004","subitem_relation_type_select":"DOI"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2212-5345","subitem_source_identifier_type":"ISSN"}]},"item_3_source_id_20":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"2212-5353","subitem_source_identifier_type":"ISSN"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kishaba, Tomoo"}]},{"creatorNames":[{"creatorName":"Hozumi, Hironao"}]},{"creatorNames":[{"creatorName":"Fujisawa, Tomoyuki"}]},{"creatorNames":[{"creatorName":"Nei, Yuichiro"}]},{"creatorNames":[{"creatorName":"Enomoto, Noriyuki"}]},{"creatorNames":[{"creatorName":"Sugiura, Hiroaki"}]},{"creatorNames":[{"creatorName":"Kitani, Masashi"}]},{"creatorNames":[{"creatorName":"Suda, Takafumi"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-07-01"}],"displaytype":"detail","filename":"Respir Investig-58-177.pdf","filesize":[{"value":"998.7 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"Respir Investig-58-177.pdf","url":"https://hama-med.repo.nii.ac.jp/record/3736/files/Respir Investig-58-177.pdf"},"version_id":"92396f23-0736-49b7-9ccf-05d9ee7e60b0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Acute exacerbation","subitem_subject_scheme":"Other"},{"subitem_subject":"diffusing capacity of the lung for carbon monoxide","subitem_subject_scheme":"Other"},{"subitem_subject":"fibroblastic foci","subitem_subject_scheme":"Other"},{"subitem_subject":"idiopathic pulmonary fibrosis","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Predictors of Acute Exacerbation in Biopsy-proven Idiopathic Pulmonary Fibrosis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Predictors of Acute Exacerbation in Biopsy-proven Idiopathic Pulmonary Fibrosis","subitem_title_language":"en"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-07-01"},"publish_date":"2021-07-01","publish_status":"0","recid":"3736","relation_version_is_last":true,"title":["Predictors of Acute Exacerbation in Biopsy-proven Idiopathic Pulmonary Fibrosis"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-08-02T05:24:11.947384+00:00"}