{"created":"2023-06-20T15:49:12.228835+00:00","id":3774,"links":{},"metadata":{"_buckets":{"deposit":"1bfc3f3d-9602-4cfd-8129-bbcaa166d475"},"_deposit":{"created_by":4,"id":"3774","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"3774"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00003774","sets":["1:11"]},"author_link":[],"item_3_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"HDAC3 is involved in NER"}]},"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-09","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"1378","bibliographicPageStart":"1367","bibliographicVolumeNumber":"18","bibliographic_titles":[{"bibliographic_title":"Molecular Cancer Research"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Recent studies have demonstrated that lysine acetylation of histones is crucial for nucleotide excision repair (NER) by relaxing the chromatin structure, which facilitates the recruitment of repair factors. However, few studies have focused on the contribution of histone deacetylases (HDACs) to NER. Here, we found that histone H3 Lys14 (H3K14) was deacetylated by HDAC3 after UV irradiation. Depletion of HDAC3 caused defects in cyclobutene pyrimidine dimer excision and sensitized cells to UV irradiation. HDAC3-depleted cells had impaired unscheduled DNA synthesis, but not recovery of RNA synthesis, which indicates that HDAC3 was required for global genome NER. Moreover, accumulation of XPC at the local UV-irradiated area was attenuated in HDAC3-depleted cells. In addition to the delay of XPC accumulation at DNA damage sites, ubiquitylation of XPC was inhibited in HDAC3-depleted cells. These results suggest that the deacetylation of histone H3K14 by HDAC3 after UV irradiation contributes to XPC recruitment to DNA lesions to promote global genome NER.","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"American Association for Cancer Research"}]},"item_3_relation_26":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"32527949","subitem_relation_type_select":"PMID"}}]},"item_3_relation_28":{"attribute_name":"出版社DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1158/1541-7786.MCR-20-0214","subitem_relation_type_select":"DOI"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"\"\"\"This manuscript has been accepted for publication in \"\"\"\"Molecular Cancer Research\"\"\"\", which is published by the American Association for Cancer Research.\"\"\""}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1541-7786","subitem_source_identifier_type":"ISSN"}]},"item_3_source_id_20":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"1557-3125","subitem_source_identifier_type":"ISSN"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nishimoto, Koji"}]},{"creatorNames":[{"creatorName":"Niida, Hiroyuki"}]},{"creatorNames":[{"creatorName":"Uchida, Chiharu"}]},{"creatorNames":[{"creatorName":"Ohhata, Tatsuya"}]},{"creatorNames":[{"creatorName":"Kitagawa, Kyoko"}]},{"creatorNames":[{"creatorName":"Motegi, Akira"}]},{"creatorNames":[{"creatorName":"Suda, Takafumi"}]},{"creatorNames":[{"creatorName":"Kitagawa, Masatoshi"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-10-01"}],"displaytype":"detail","filename":"Mol. Cancer Res.-18-1367.pdf","filesize":[{"value":"11.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Mol. Cancer Res.-18-1367.pdf","url":"https://hama-med.repo.nii.ac.jp/record/3774/files/Mol. Cancer Res.-18-1367.pdf"},"version_id":"b55c16df-8bcd-4464-9b6b-5cfbffdee8da"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Histone deacetylase 3","subitem_subject_scheme":"Other"},{"subitem_subject":"XPC","subitem_subject_scheme":"Other"},{"subitem_subject":"Histone H3K14","subitem_subject_scheme":"Other"},{"subitem_subject":"Ultraviolet","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"HDAC3 Is Required for XPC Recruitment and Nucleotide Excision Repair of DNA Damage Induced by UV Irradiation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"HDAC3 Is Required for XPC Recruitment and Nucleotide Excision Repair of DNA Damage Induced by UV Irradiation","subitem_title_language":"en"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-10-01"},"publish_date":"2021-10-01","publish_status":"0","recid":"3774","relation_version_is_last":true,"title":["HDAC3 Is Required for XPC Recruitment and Nucleotide Excision Repair of DNA Damage Induced by UV Irradiation"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-08-02T07:42:18.751740+00:00"}