{"created":"2023-06-20T15:49:12.368114+00:00","id":3777,"links":{},"metadata":{"_buckets":{"deposit":"ff916205-d653-4d48-9058-989108bd50c2"},"_deposit":{"created_by":4,"id":"3777","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"3777"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00003777","sets":["1:11"]},"author_link":[],"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"379","bibliographicPageStart":"369","bibliographicVolumeNumber":"77","bibliographic_titles":[{"bibliographic_title":"European Journal of Clinical Pharmacology"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: Serum markers of renal function have not been characterized in patients treated with itraconazole (ITZ). This study aimed to evaluate the associations between plasma ITZ and its hydroxylated metabolite (OH-ITZ) concentrations and serum markers of renal function in hematopoietic or immune-related disorder patients.\nMethods: This study enrolled 40 hematopoietic or immune-related disorder patients receiving oral ITZ solution. Plasma concentrations of ITZ and OH-ITZ at 12 hours after dosing were determined at steady state. Their relationships with serum levels of creatinine and cystatin C, and their estimated glomerular filtration rate (eGFR) were evaluated.\nResults: The free plasma concentration of ITZ had no correlation with serum creatinine and serum creatinine-based estimated glomerular filtration rate (eGFR-cre). The free plasma concentration of OH-ITZ was positively and negatively correlated with serum creatinine and eGFR-cre, respectively. The free plasma concentrations of ITZ and OH-ITZ had no association with serum cystatin C and serum cystatin C-based eGFR. Serum creatinine was higher by 16% after than before starting ITZ treatment, while eGFR-cre was lower by 9.3%. The serum creatinine ratio after/before ITZ treatment was positively correlated with the free plasma concentration of OH-ITZ. The patients co-treated with trimethoprim-sulfamethoxazole had higher serum creatinine. Concomitant glucocorticoid administration did not significantly alter serum cystatin C.\nConclusions: Hematopoietic or immune-related disorder patients treated with oral ITZ had a higher level of serum creatinine. Although serum creatinine potentially increases in conjunction with the free plasma concentration of OH-ITZ, concomitant ITZ administration has a slight impact on the eGFR-cre level in clinical settings.","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature "}]},"item_3_relation_26":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"33033881","subitem_relation_type_select":"PMID"}}]},"item_3_relation_28":{"attribute_name":"出版社DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/s00228-020-03010-y","subitem_relation_type_select":"DOI"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"\"This is a post-peer-review, pre-copyedit version of an article published in \"\"European Journal of Clinical Pharmacology\"\". The final authenticated version is available online at: https://doi.org/10.1007/s00228-020-03010-y.\""}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0031-6970 ","subitem_source_identifier_type":"ISSN"}]},"item_3_source_id_20":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"1432-1041 ","subitem_source_identifier_type":"ISSN"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Imoto, Yumi"}]},{"creatorNames":[{"creatorName":"Naito, Takafumi"}]},{"creatorNames":[{"creatorName":"Miyadera, Yukari"}]},{"creatorNames":[{"creatorName":"Ono, Takaaki"}]},{"creatorNames":[{"creatorName":"Kawakami, Junichi"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-10-08"}],"displaytype":"detail","filename":"EJCP-77-369.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"EJCP-77-369.pdf","url":"https://hama-med.repo.nii.ac.jp/record/3777/files/EJCP-77-369.pdf"},"version_id":"9de82d04-b443-4b22-bc90-680253f5f617"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"itraconazole","subitem_subject_scheme":"Other"},{"subitem_subject":"metabolite","subitem_subject_scheme":"Other"},{"subitem_subject":"pharmacokinetics","subitem_subject_scheme":"Other"},{"subitem_subject":"creatinine","subitem_subject_scheme":"Other"},{"subitem_subject":"renal function","subitem_subject_scheme":"Other"},{"subitem_subject":"cystatin C","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Associations between plasma hydroxylated metabolite of itraconazole and serum creatinine in patients with a hematopoietic or immune-related disorder","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Associations between plasma hydroxylated metabolite of itraconazole and serum creatinine in patients with a hematopoietic or immune-related disorder","subitem_title_language":"en"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-10-08"},"publish_date":"2021-10-08","publish_status":"0","recid":"3777","relation_version_is_last":true,"title":["Associations between plasma hydroxylated metabolite of itraconazole and serum creatinine in patients with a hematopoietic or immune-related disorder"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-08-02T07:42:26.708437+00:00"}