{"created":"2023-06-20T15:49:12.482783+00:00","id":3779,"links":{},"metadata":{"_buckets":{"deposit":"b614b39c-3271-40c7-82be-dae64908a85d"},"_deposit":{"created_by":4,"id":"3779","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"3779"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00003779","sets":["1:11"]},"author_link":[],"item_3_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Impact of CYP2D6 and Cachexia on Tramadol Kinetics"}]},"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"481","bibliographicPageStart":"472","bibliographicVolumeNumber":"128","bibliographic_titles":[{"bibliographic_title":"Basic & Clinical Pharmacology & Toxicology"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"This study aimed to evaluate the influence of CYP2D6 activity and cachexia progression on the enantiomeric alteration of plasma tramadol and its demethylated metabolites in head and neck cancer patients. Fifty-three head and neck cancer patients receiving oral tramadol were enrolled. The plasma concentrations of tramadol, O-desmethyltramadol (ODT), and N-desmethyltramadol (NDT) enantiomers were determined. The CYP2D6 activity score (AS) and degree of cachexia progression were assessed according to genotype and the Glasgow Prognostic Score (GPS), respectively. The enantiomeric ratio of NDT was (+)-form dominant in all patients. CYP2D6 AS had negative correlations with the plasma concentrations of (+)-NDT and (?)-NDT. The plasma concentrations of (+)-tramadol and (+)-ODT were higher in patients with GPS 1 or 2 than in those with GPS 0. Lower metabolic ratios to NDT enantiomers were observed in patients with GPS 1 or 2. In patients with GPS 1 or 2, the plasma (?)-tramadol was associated with the incidence of central nervous system symptoms. In conclusion, CYP2D6 AS partially explained the contribution of CYP2D6 activity to plasma tramadol and its demethylated metabolite enantiomers. Additionally, cachexia progression elevated the plasma (+)-tramadol and (+)-ODT levels through the reduction of N-demethylation of (+)-tramadol.","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"John Wiley and Sons"}]},"item_3_relation_26":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"33131142 ","subitem_relation_type_select":"PMID"}}]},"item_3_relation_28":{"attribute_name":"出版社DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1111/bcpt.13528","subitem_relation_type_select":"DOI"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"\"This is the peer reviewed version of the following article: \"\"Impact of CYP2D6 Activity and Cachexia Progression on Enantiomeric Alteration of Plasma Tramadol and Its Demethylated Metabolites and Their Relationships with Central Nervous System Symptoms in Head and Neck Cancer Patients\"\", Basic & Clinical Pharmacology & Toxicology; 128(3): p472-481, 2021, which has been published in final form at https://doi.org/10.1111/bcpt.13528. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.\""}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1742-7835","subitem_source_identifier_type":"ISSN"}]},"item_3_source_id_20":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"1742-7843","subitem_source_identifier_type":"ISSN"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Suzuki, Koji"}]},{"creatorNames":[{"creatorName":"Naito, Takafumi"}]},{"creatorNames":[{"creatorName":"Tanaka, Hironari"}]},{"creatorNames":[{"creatorName":"Shibata, Kaito"}]},{"creatorNames":[{"creatorName":"Yamada, Yasuhide"}]},{"creatorNames":[{"creatorName":"Itoh, Kunihiko"}]},{"creatorNames":[{"creatorName":"Kawakami, Junichi"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-10-31"}],"displaytype":"detail","filename":"BCPT-128-472.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"BCPT-128-472.pdf","url":"https://hama-med.repo.nii.ac.jp/record/3779/files/BCPT-128-472.pdf"},"version_id":"d0b7ccd1-5756-46ad-a271-2cda1a36ea3a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"tramadol","subitem_subject_scheme":"Other"},{"subitem_subject":"enantiomers","subitem_subject_scheme":"Other"},{"subitem_subject":"metabolite","subitem_subject_scheme":"Other"},{"subitem_subject":"CYP2D6","subitem_subject_scheme":"Other"},{"subitem_subject":"cancer cachexia","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Impact of CYP2D6 Activity and Cachexia Progression on Enantiomeric Alteration of Plasma Tramadol and Its Demethylated Metabolites and Their Relationships with Central Nervous System Symptoms in Head and Neck Cancer Patients","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Impact of CYP2D6 Activity and Cachexia Progression on Enantiomeric Alteration of Plasma Tramadol and Its Demethylated Metabolites and Their Relationships with Central Nervous System Symptoms in Head and Neck Cancer Patients","subitem_title_language":"en"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-10-26"},"publish_date":"2021-10-26","publish_status":"0","recid":"3779","relation_version_is_last":true,"title":["Impact of CYP2D6 Activity and Cachexia Progression on Enantiomeric Alteration of Plasma Tramadol and Its Demethylated Metabolites and Their Relationships with Central Nervous System Symptoms in Head and Neck Cancer Patients"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-08-02T07:42:30.854340+00:00"}