{"created":"2023-06-20T15:49:13.180521+00:00","id":3793,"links":{},"metadata":{"_buckets":{"deposit":"89c3b7cc-8a2f-4a4d-91cc-e18eaecdd3cc"},"_deposit":{"created_by":4,"id":"3793","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"3793"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00003793","sets":["1:11"]},"author_link":[],"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"4263","bibliographicPageStart":"4253","bibliographicVolumeNumber":"31","bibliographic_titles":[{"bibliographic_title":"European Radiology "}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objectives- To study the pulmonary artery (PA) hemodynamics in patients with systemic sclerosis (SSc) using 4D flow MRI (4D-Flow).\nMethods - Twenty-three patients with SSc (M/F: 2/21, 57±15 years, 3 manifest PA hypertension (PAH) by right heart catheterization) and 10 control subjects (M/F: 1/9, 55±17 years) underwent 4D-Flow for the in vivo measurement of 3D blood flow velocities in the PA. Data analysis included area-averaged flow quantification at the main PA, 3D wall shear stress (WSS), oscillatory shear index (OSI) calculation along the PA surface and Reynolds number. The composite outcome of all-cause death and major adverse cardiac events was also investigated.\nResults- The maximum PA flow at the systole didn’t differ, but the minimum flow at the diastole was significantly greater in patients with SSc compared to that in control subjects (7.7±16.0 ml/s vs. -13.0±17.3 ml/s, p<0.01). The maximum WSS at the peak systole was significantly lower and OSI was significantly greater in patients with SSc compared to those in control subjects (maximum WSS: 1.04±0.20 Pa vs. 1.33±0.34 Pa, p<0.01, OSI: 0.139±0.031 vs. 0.101±0.037, p<0.01). The cumulative event-free rate for the composite event were significantly lower in patients with minimum flow in main PA?9.22 ml/s (p=0.012) and in patients with Reynolds number?2560 (p<0.001).\nConclusions- 4D-Flow has the potential to detect changes of PA hemodynamics noninvasively and predict the outcome in patients with SSc at the stage before manifest PAH.","subitem_description_type":"Abstract"},{"subitem_description":"Key points\n・The WSS at the peak systolic phase was significantly lower (p<0.05), whereas OSI were greater (p<0.01) in patients with SSc without manifest PAH than controls.\n・The hemodynamic change detected by 4D-Flow may help patient management even at the stage before manifest PAH in SSc.\n・The minimum PA flow and Reynolds number by 4D-Flow will serve as a predictive marker for SSc.","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature"}]},"item_3_relation_26":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"33211148","subitem_relation_type_select":"PMID"}}]},"item_3_relation_28":{"attribute_name":"出版社DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/s00330-020-07301-x","subitem_relation_type_select":"DOI"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"\"This is a post-peer-review, pre-copyedit version of an article published in \"\"European Radiology\"\". The final authenticated version is available online at: http://dx.doi.org/10.1007/s00330-020-07301-x.\""}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0938-7994 ","subitem_source_identifier_type":"ISSN"}]},"item_3_source_id_20":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"1432-1084","subitem_source_identifier_type":"ISSN"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ikoma, Takenori"}]},{"creatorNames":[{"creatorName":"Suwa, Kenichiro"}]},{"creatorNames":[{"creatorName":"Sano, Makoto"}]},{"creatorNames":[{"creatorName":"Ushio, Takasuke"}]},{"creatorNames":[{"creatorName":"Saotome, Masao"}]},{"creatorNames":[{"creatorName":"Ogawa, Noriyoshi"}]},{"creatorNames":[{"creatorName":"Satoh, Hiroshi"}]},{"creatorNames":[{"creatorName":"Maekawa, Yuichiro"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-11-19"}],"displaytype":"detail","filename":"ER-31-4253.pdf","filesize":[{"value":"2.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ER-31-4253.pdf","url":"https://hama-med.repo.nii.ac.jp/record/3793/files/ER-31-4253.pdf"},"version_id":"6a92c1be-0261-4d30-94ac-6c47978549b6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Magnetic resonance imaging","subitem_subject_scheme":"Other"},{"subitem_subject":"pulmonary artery","subitem_subject_scheme":"Other"},{"subitem_subject":"hemodynamics","subitem_subject_scheme":"Other"},{"subitem_subject":"blood flow velocity","subitem_subject_scheme":"Other"},{"subitem_subject":"systemic sclerosis","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Early changes of pulmonary arterial hemodynamics in patients with systemic sclerosis: Flow pattern, WSS and OSI analysis with 4D Flow MRI","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Early changes of pulmonary arterial hemodynamics in patients with systemic sclerosis: Flow pattern, WSS and OSI analysis with 4D Flow MRI","subitem_title_language":"en"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-11-01"},"publish_date":"2021-11-01","publish_status":"0","recid":"3793","relation_version_is_last":true,"title":["Early changes of pulmonary arterial hemodynamics in patients with systemic sclerosis: Flow pattern, WSS and OSI analysis with 4D Flow MRI"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-08-02T07:42:44.072705+00:00"}