@article{oai:hama-med.repo.nii.ac.jp:00003815,
 author = {Miura, Katsutoshi and Yamashita, Kanna},
 issue = {12},
 journal = {Ultrasound in Medicine & Biology},
 month = {Dec},
 note = {Scanning acoustic microscopy reveals information about histology and speed-of-sound (SOS) through tissues. Slower SOS corresponds to lower stiffness. The present study aimed to investigate whether SOS values reflect the degree of degeneration with aging or dissection and whether enzymatic digestion susceptibility is distinct. SOS of media besides the atheromatous areas of normal and surgical dissections was measured and compared using medial degeneration grade (MDG) scores. To evaluate the damage rate, SOS was assessed following collagenase digestion. SOS scores negatively correlated with aging and MDG scores. Dissected aortae showed higher SOS and MDG scores without age correlation. Collagenase digestion was present in all aortae, but older aortae were more injured than younger aortae. Dissected aortae were more vulnerable to collagenase. Older and dissected aortae expressed specific extracellular matrix (ECM) components to compensate for mechanical weakness. The present method can evaluate mechanical weakness corresponding to histology to investigate the cause of rupture.},
 pages = {3102--3115},
 title = {Mechanical weakness of thoracic aorta related to aging or dissection predicted by speed-of-sound with collagenase},
 volume = {45},
 year = {2019}
}