{"created":"2023-06-20T15:49:14.931475+00:00","id":3823,"links":{},"metadata":{"_buckets":{"deposit":"ec161f5d-923a-49d3-950e-047c85d8e10a"},"_deposit":{"created_by":4,"id":"3823","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"3823"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00003823","sets":["1:11"]},"author_link":["11413","11417","11414","11415","11412","11416"],"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11-12","bibliographicPageEnd":"854","bibliographicPageStart":"843","bibliographicVolumeNumber":"17","bibliographic_titles":[{"bibliographic_title":"Expert Review of Proteomics"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Introduction: Imaging is a technique used for direct visualization of the internal structure or distribution of biomolecules of a living system in a two-dimensional or three-dimensional fashion. Phospholipids are important structural components of biological membranes and have been reported to be associated with various human diseases. Therefore, the visualization of phospholipids is crucial to understand the underlying mechanism of cellular and molecular processes in normal and diseased conditions.\nAreas covered: Mass spectrometry imaging (MSI) has enabled the label-free imaging of individual phospholipids in biological tissues and cells. The commonly used MSI techniques include matrix-assisted laser desorption ionization-MSI (MALDI-MSI), desorption electrospray ionization-MSI (DESI-MSI), and secondary ion mass spectrometry (SIMS) imaging. This special report described those methods, summarized the findings, and discussed the future development for the imaging of phospholipids.\nExpert opinion: Phospholipids imaging in complex biological samples has been  significantly benefited from the development of MSI methods. In MALDI-MSI, novel matrix that produces homogenous crystals exclusively with polar lipids is important for phospholipids imaging with greater efficiency and higher spatial resolution. DESI-MSI has the potential of live imaging of the biological surface while SIMS is expected to image at the subcellular level in the near future.","subitem_description_type":"Abstract"},{"subitem_description":"Highlights:\n1. Mass spectrometry imaging (MSI) is a powerful method for imaging specific phospholipids (PLs) in tissues and cells.\n2. The potential of MSI of either single or multiple PLs for the development of therapeutic agents, biomarkers, and predictive factors for diseases is reviewed.\n3. The current states of MALDI-MSI, DESI-MSI, and SIMS-MSI on tissue PL imaging are assessed and discussed.\n4. By image reconstruction, conventional 2D imaging can be applied in 3D PL imaging.","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Taylor & Francis"}]},"item_3_relation_26":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"33504247","subitem_relation_type_select":"PMID"}}]},"item_3_relation_28":{"attribute_name":"出版社DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1080/14789450.2020.1880897","subitem_relation_type_select":"DOI"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This is an Accepted Manuscript of an article published by Taylor & Francis in \"Expert Review of Proteomics\" on 28/01/2021, available online: http://www.tandfonline.com/10.1080/14789450.2020.1880897."}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1478-9450","subitem_source_identifier_type":"ISSN"}]},"item_3_source_id_20":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"1744-8387","subitem_source_identifier_type":"ISSN"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mamun, Md. Al"}],"nameIdentifiers":[{"nameIdentifier":"11412","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Islam, Ariful"}],"nameIdentifiers":[{"nameIdentifier":"11413","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Eto, Fumihiro"}],"nameIdentifiers":[{"nameIdentifier":"11414","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sato, Tomohito"}],"nameIdentifiers":[{"nameIdentifier":"11415","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kahyo, Tomoaki"}],"nameIdentifiers":[{"nameIdentifier":"11416","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Setou, Mitsutoshi"}],"nameIdentifiers":[{"nameIdentifier":"11417","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-02-08"}],"displaytype":"detail","filename":"Expert Rev Proteomics-17-843.pdf","filesize":[{"value":"967.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Expert Rev Proteomics-17-843.pdf","url":"https://hama-med.repo.nii.ac.jp/record/3823/files/Expert Rev Proteomics-17-843.pdf"},"version_id":"9a518ff7-ac6a-4671-8517-660a8e861950"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Phospholipid","subitem_subject_scheme":"Other"},{"subitem_subject":"Mass spectrometry imaging","subitem_subject_scheme":"Other"},{"subitem_subject":"MALDI-MSI","subitem_subject_scheme":"Other"},{"subitem_subject":"DESI-MSI","subitem_subject_scheme":"Other"},{"subitem_subject":"SIMS imaging","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Mass spectrometry-based phospholipid imaging: methods and findings","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Mass spectrometry-based phospholipid imaging: methods and findings"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-02-08"},"publish_date":"2022-02-08","publish_status":"0","recid":"3823","relation_version_is_last":true,"title":["Mass spectrometry-based phospholipid imaging: methods and findings"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-06-20T16:24:00.413820+00:00"}