{"created":"2023-06-20T15:49:21.909305+00:00","id":3955,"links":{},"metadata":{"_buckets":{"deposit":"727c3247-7b09-4e2a-88a1-53f4dce40a19"},"_deposit":{"created_by":4,"id":"3955","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"3955"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00003955","sets":["1:11"]},"author_link":["12081","12082"],"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-02-11","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"9","bibliographicPageStart":"1","bibliographicVolumeNumber":"6","bibliographic_titles":[{"bibliographic_title":"Pathology and Laboratory Medicine International"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: A scanning acoustic microscope (SAM) uses an ultrasound to image an object by plotting the speed-of-sound (SOS) through tissues on screen. Because hard tissues result in great SOS, SAM can provide data on the tissue elasticity. This paper investigated the utility of SAM in evaluating thyroid lesions.\nMethods: Formalin-fixed, paraffin sections were scanned with a 120 MHz transducer. SOS through each area was calculated and plotted on the screen to provide histological images, and SOS of each lesion was compared and statistically analyzed.\nResults: High-concentrated colloids, red blood cells, and collagen fibers showed great SOS, while low-concentrated colloids, parathyroids, lymph follicles, and epithelial tissues including carcinomas demonstrated lower SOS. SAM clearly discriminated structure of thyroid components corresponding to low magnification of light microscopy. Thyroid tumors were classified into three groups by average SOS: the fast group consisted of follicular adenomas/carcinomas and malignant lymphomas; the slow group contained poorly differentiated/undifferentiated carcinomas; and the intermediate group comprised papillary/medullary carcinomas. Fragmented colloids, irregular-shaped follicles, and desmoplastic reactions were observed in the invasive area of surrounding carcinomas.\nConclusion: The SAM imaging method had the following benefits: 1) precise images were acquired in a few minutes without special staining; 2) structural irregularity and desmoplastic reactions, which indicated malignancy, were detected; 3) images reflected tissue elasticity, which was statistically comparable among lesions by SOS; 4) follicular functional activity was predictable by converting colloid concentration to SOS; and 5) tumor classification was predictable by SOS because more poorly differentiated carcinomas had a tendency to show lower SOS.","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Dovepress"}]},"item_3_relation_28":{"attribute_name":"出版社DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.2147/PLMI.S58343","subitem_relation_type_select":"DOI"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2014 Miura and Mineta. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1179-2698","subitem_source_identifier_type":"ISSN"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Miura, Katsutoshi"}],"nameIdentifiers":[{"nameIdentifier":"12081","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mineta, Hiroyuki"}],"nameIdentifiers":[{"nameIdentifier":"12082","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-03-15"}],"displaytype":"detail","filename":"PLMI-6-1.pdf","filesize":[{"value":"7.7 MB"}],"format":"application/pdf","licensetype":"license_9","mimetype":"application/pdf","url":{"label":"PLMI-6-1.pdf","url":"https://hama-med.repo.nii.ac.jp/record/3955/files/PLMI-6-1.pdf"},"version_id":"01f39715-0d7e-4ae7-872c-a737363de587"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"scanning acoustic microscope","subitem_subject_scheme":"Other"},{"subitem_subject":"tissue elasticity","subitem_subject_scheme":"Other"},{"subitem_subject":"cancer imaging","subitem_subject_scheme":"Other"},{"subitem_subject":"thyroid tumor","subitem_subject_scheme":"Other"},{"subitem_subject":"parathyroid","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Histological evaluation of thyroid lesions using a scanning acoustic microscope","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Histological evaluation of thyroid lesions using a scanning acoustic microscope"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-03-15"},"publish_date":"2022-03-15","publish_status":"0","recid":"3955","relation_version_is_last":true,"title":["Histological evaluation of thyroid lesions using a scanning acoustic microscope"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-06-20T16:21:59.081053+00:00"}