{"created":"2023-06-20T15:49:22.034386+00:00","id":3957,"links":{},"metadata":{"_buckets":{"deposit":"e9b35d6a-7023-46d2-94eb-e65d9f73cc42"},"_deposit":{"created_by":4,"id":"3957","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"3957"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00003957","sets":["1:11"]},"author_link":["12087","12088","12085","12089","12090","12086","12091"],"item_3_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Ultrasound detection of tissue modification"}]},"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"366","bibliographicPageStart":"355","bibliographicVolumeNumber":"65","bibliographic_titles":[{"bibliographic_title":"Pathology International"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A scanning acoustic microscope (SAM) calculates the speed of sound (SOS) through tissues and plots the data on the screen to form images. Hard tissues result in greater SOS; based on these differences in tissue properties regarding SOS, SAM can provide data on tissue elasticity. The present study evaluated whether tissue modifications, such as formalin fixation, periodic acid-Schiff (PAS) reactions and protein degradation, changed the acoustic properties of the tissues and whether SAM could be a useful tool for following chemical changes in sections. The fixation process was observable by the increased SOS. During the PAS reaction, the glycosylation of tissues was characterized by an increased SOS. Mucous or glycogen distribution was visualised and was found to be statistically comparable among lesions and states. Protease digestion by pepsin led to a decreased SOS. Tissue sensitivity to proteases varied due to the stage, cause and duration of inflammation or ageing. Changes in acoustic properties were more sensitive than those in optical histology. SAM facilitates the visualisation of the time course or distribution of chemical modifications in tissue sections, thus aiding their comparison among tissues. SAM may be an effective tool for studying changes such as protein cross-linkage, tissue repair and ageing.","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"John Wiley and Sons "}]},"item_3_relation_26":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"25824722","subitem_relation_type_select":"PMID"}}]},"item_3_relation_27":{"attribute_name":"医中誌論文ID","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"2016231362","subitem_relation_type_select":"ICHUSHI"}}]},"item_3_relation_28":{"attribute_name":"出版社DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1111/pin.12288","subitem_relation_type_select":"DOI"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This is the peer reviewed version of the following article: \"Microscopic observation of chemical modification in sections using scanning acoustic microscopy\", Pathology International; 65(7): p355-366, 2015, which has been published in final form at https://doi.org/10.1111/pin.12288. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited."}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1320-5463","subitem_source_identifier_type":"ISSN"}]},"item_3_source_id_20":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"1440-1827","subitem_source_identifier_type":"ISSN"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Miura, Katsutoshi"}],"nameIdentifiers":[{"nameIdentifier":"12085","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Egawa, Yuki"}],"nameIdentifiers":[{"nameIdentifier":"12086","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Moriki, Toshiaki"}],"nameIdentifiers":[{"nameIdentifier":"12087","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mineta, Hiroyuki"}],"nameIdentifiers":[{"nameIdentifier":"12088","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Harada, Hidekazu"}],"nameIdentifiers":[{"nameIdentifier":"12089","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Baba, Satoshi"}],"nameIdentifiers":[{"nameIdentifier":"12090","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamamoto, Seiji"}],"nameIdentifiers":[{"nameIdentifier":"12091","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-03-15"}],"displaytype":"detail","filename":"Pathol Int-65-355.pdf","filesize":[{"value":"2.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Pathol Int-65-355.pdf","url":"https://hama-med.repo.nii.ac.jp/record/3957/files/Pathol Int-65-355.pdf"},"version_id":"7bd1468a-50ef-4287-8455-05179191a16b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ageing","subitem_subject_scheme":"Other"},{"subitem_subject":"elasticity","subitem_subject_scheme":"Other"},{"subitem_subject":"formalin fixation","subitem_subject_scheme":"Other"},{"subitem_subject":"histochemistry","subitem_subject_scheme":"Other"},{"subitem_subject":"histopathology","subitem_subject_scheme":"Other"},{"subitem_subject":"imaging analysis","subitem_subject_scheme":"Other"},{"subitem_subject":"pepsin","subitem_subject_scheme":"Other"},{"subitem_subject":"periodic acid-Schiff reaction","subitem_subject_scheme":"Other"},{"subitem_subject":"ultrasound","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Microscopic observation of chemical modification in sections using scanning acoustic microscopy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Microscopic observation of chemical modification in sections using scanning acoustic microscopy"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-03-15"},"publish_date":"2022-03-15","publish_status":"0","recid":"3957","relation_version_is_last":true,"title":["Microscopic observation of chemical modification in sections using scanning acoustic microscopy"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-06-20T16:21:56.876221+00:00"}