@article{oai:hama-med.repo.nii.ac.jp:00004001,
 author = {今井, 篤志 and 三澤, 清 and 山田, 智史 and 岡村, 純 and 望月, 大極 and 山口, 裕貴 and 瀧澤, 義徳 and 細川, 誠二 and 峯田, 周幸},
 journal = {耳鼻咽喉科臨床　補冊 = Practica oto-rhino-laryngologica. Suppl.},
 month = {Feb},
 note = {浜松医科大学医学部耳鼻咽喉科・頭頸部外科学教室　峯田周幸教授退任記念論文集～症例から学ぶ～, Festschrift for Professor Hiroyuki Mineta In Hornor of His Retirement as Chairman of Hamamatsu University School of Medicine, Liquid biopsy has the alternative utility, besides being a diagnostic tool, as a minimally invasive monitoring tool for disease profiling and prognostication. Recently, the incidence of HPV-associated oropharyngeal cancer has been increasing. Also, the choices of chemotherapy, including immune checkpoint inhibitor therapy, has been increasing. A minimally invasive diagnostic tool is desired.
Herein, we demonstrate the usefulness of liquid biopsy, not only for HPV ctDNA monitoring, but also for diagnosis of recurrence, in a patient with HPV-OPC. The ctDNA concentrations decreased and serum HPV-DNA became negative after surgery for the primary tumor. When the patient developed a pulmonary lesion during the follow-up after initial treatment, we initially suspected primary lung cancer clinically. The operated lesion turned out to be a metastatic lesion. The test for HPV-DNA, which had become negative before, had become positive before the pulmonary surgery, suggesting recurrent disease.
Liquid biopsy for monitoring of the ctDNA has the potential to allow the disease status to be monitored in patients with HPV-OPC.},
 pages = {1--7},
 title = {HPV関連中咽頭癌例に対する血液循環腫瘍DNAを用いたリキッドバイオプシーの有用性},
 volume = {156},
 year = {2021}
}