{"created":"2023-06-20T15:49:28.012480+00:00","id":4058,"links":{},"metadata":{"_buckets":{"deposit":"3ec5ed74-401c-4645-9dc3-de1fa3b62d11"},"_deposit":{"created_by":4,"id":"4058","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"4058"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00004058","sets":["1:11"]},"author_link":["12633"],"item_3_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"特集：先天性サイトメガロウイルス感染症と難聴 ―診断・予防・治療―"}]},"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-08-15","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"17","bibliographicPageStart":"12","bibliographicVolumeNumber":"261","bibliographic_titles":[{"bibliographic_title":"Monthly Book ENTONI = エントーニ"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"大脳は先天性ヒトサイトメガロウイルス（human cytomegalovirus：HCMV）感染において重要な標的臓器である．神経前駆細胞は脳細胞の中でHCMVに対する感染感受性が最も高く，ウイルス増殖性・細胞溶解性感染を呈し，感染細胞は死滅する．妊娠初期(~15週)では脳室壁の神経前駆細胞の増殖・分化・移動による脳形成―大脳皮質板形成―が最も旺盛で，この時期に感染すると脳障害の頻度が高く小頭症等の重篤な脳奇形を発症し易い．マウスCMV(MCMV)を用いた胎内感染モデルでも同様の結果が得られている．一方，マウス新生仔脳内感染モデルでは，発育期大脳神経細胞において細胞破壊を伴わない一過性で特異な持続感染が認められる．この様な感染で機能障害を伴った神経細胞がその後も生存し，神経精神発達障害の要因となる可能性がある．同様の感染をヒト先天性HCMV感染症で明らかにした報告は未だなく，今後の検証が期待される．","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"全日本病院出版会"}]},"item_3_relation_27":{"attribute_name":"医中誌論文ID","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"2021310290","subitem_relation_type_select":"ICHUSHI"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"出版者の許諾を得て掲載"},{"subitem_rights":"著作権者の保有する原稿であるため、実際に出版されたものとは異なる内容・誌面となっているケースがあります。"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1346-2067","subitem_source_identifier_type":"ISSN"}]},"item_3_source_id_23":{"attribute_name":"NII書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA11549586","subitem_source_identifier_type":"NCID"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小杉, 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transmission","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"microcephaly","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"neuropsychiatric disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"neural precursor cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cerebral neuron","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal 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