{"created":"2023-06-20T15:49:28.274488+00:00","id":4062,"links":{},"metadata":{"_buckets":{"deposit":"f8f034c7-ceee-4a17-b717-847cc66fdcc1"},"_deposit":{"created_by":4,"id":"4062","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"4062"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00004062","sets":["1:11"]},"author_link":["12657","12658","12659","12660","12661","12662","12663","12664","12665"],"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"953","bibliographicPageStart":"944","bibliographicVolumeNumber":"45","bibliographic_titles":[{"bibliographic_title":"Hypertension Research"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Excessive salt intake causes hypertension and heart diseases. B-type natriuretic peptide (BNP) is a surrogate marker of heart disease, and a slightly elevated BNP level is associated with a poor prognosis. Our previous cross-sectional study demonstrated that plasma BNP has a significant positive association with daily salt intake in the general population. However, the relationship between changes in salt intake and changes in plasma BNP remains unknown.\nWe recruited 3051 participants without hypertension or electrocardiogram abnormalities who underwent annual health check-ups for two consecutive years. Clinical parameters, including plasma BNP, were obtained, and daily salt intake was evaluated using urinary samples. Annual changes in these parameters were calculated.\nThe median plasma BNP level was 12.9pg/mL, and the daily salt intake was 8.73±1.89g. The annual changes in plasma BNP and daily salt intake were 4.79±36.38% and 2.01±21.80%, respectively. Participants in the highest quartile of annual changes in daily salt intake showed the largest annual changes in plasma BNP. Annual changes in plasma BNP indicated a significant positive association with daily salt intake. Moreover, multiple linear regression analyses revealed that annual changes in plasma BNP showed a significant positive association with daily salt intake after adjustments.\nOur study showed a significant positive relationship between annual changes in plasma BNP and annual changes in daily salt intake. The suppression of plasma BNP is therefore induced by salt intake restriction. The monitoring of plasma BNP while reducing salt intake may therefore prevent heart diseases and lead to improved prognoses in the general population without heart diseases.","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature"},{"subitem_publisher":"日本高血圧学会 = The Japanese Society of Hypertension"}]},"item_3_relation_26":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"35422510","subitem_relation_type_select":"PMID"}}]},"item_3_relation_28":{"attribute_name":"出版社DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/s41440-022-00914-3","subitem_relation_type_select":"DOI"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1038/s41440-022-00914-3"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0916-9636","subitem_source_identifier_type":"ISSN"}]},"item_3_source_id_20":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"1348-4214","subitem_source_identifier_type":"ISSN"}]},"item_3_source_id_23":{"attribute_name":"NII書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA10847079","subitem_source_identifier_type":"NCID"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ohashi, Naro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takase, Hiroyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Aoki, Taro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishigaki, Sayaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Iwakura, Takamasa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Isobe, Shinsuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujikura, Tomoyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kato, Akihiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yasuda, Hideo"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-10-14"}],"displaytype":"detail","filename":"Hypertens Res-45-944.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Hypertens Res-45-944.pdf","url":"https://hama-med.repo.nii.ac.jp/record/4062/files/Hypertens Res-45-944.pdf"},"version_id":"e17a88d0-6063-481b-b979-ec4f29740f8e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Annual change","subitem_subject_scheme":"Other"},{"subitem_subject":"B-type natriuretic peptide","subitem_subject_scheme":"Other"},{"subitem_subject":"General population","subitem_subject_scheme":"Other"},{"subitem_subject":"Salt intake","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Positive relationships between annual changes in salt intake and plasma B-type natriuretic peptide levels in the general population without hypertension and heart diseases","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Positive relationships between annual changes in salt intake and plasma B-type natriuretic peptide levels in the general population without hypertension and heart diseases","subitem_title_language":"en"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-10-11"},"publish_date":"2022-10-11","publish_status":"0","recid":"4062","relation_version_is_last":true,"title":["Positive relationships between annual changes in salt intake and plasma B-type natriuretic peptide levels in the general population without hypertension and heart diseases"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-08-02T07:17:35.894002+00:00"}