{"created":"2023-06-20T15:49:30.948108+00:00","id":4103,"links":{},"metadata":{"_buckets":{"deposit":"43e3c53b-c88f-4f7c-a331-4daa502c1ab3"},"_deposit":{"created_by":4,"id":"4103","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"4103"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00004103","sets":["1:11"]},"author_link":["12739"],"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"116","bibliographicPageStart":"111","bibliographicVolumeNumber":"49","bibliographic_titles":[{"bibliographic_title":"臨床化学 = Japanese Journal of Clinical Chemistry"}]}]},"item_3_description_10":{"attribute_name":"注記","attribute_value_mlt":[{"subitem_description":"2019年度 学会賞受賞報告（奨励賞）","subitem_description_type":"Other"}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"大腸がんの発育進展にかかわる遺伝子不安定性にはマイクロサテライト不安定性(microsatellite instability:MSI)と染色体不安定性(chromosomal instability:CIN)がある。CINの原因として様々な報告があり定説がないのに対し、MSIの原因はDNAミスマッチ修復(MMR)機構の破綻(dMMR)であることが確認されている。今回我々はMMR機構がDNAミスマッチのみならずDNAに取り込まれた5-fluorouracil(5-FU)も認識し細胞障害を誘導することを証明した。このことはこれまでにMMR大腸がんは5-FU療法のbenefitが得られないとの臨床的な既報の内容に矛盾しない。最近、リンチ症候群のスクリーニングのみならずコンパニオン診断薬としてもMSI検査が行われるようになり、DNAミスマッチ修復機構のメカニズムの理解とその応用は重要になっていくであろう。","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本臨床化学会 = Japan Society of Clinical Chemistry"}]},"item_3_relation_27":{"attribute_name":"医中誌論文ID","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"2020275107","subitem_relation_type_select":"ICHUSHI"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"出版者の許諾を得て掲載"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0370-5633","subitem_source_identifier_type":"ISSN"}]},"item_3_source_id_20":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"2187-4077","subitem_source_identifier_type":"ISSN"}]},"item_3_source_id_23":{"attribute_name":"NII書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AN00252758","subitem_source_identifier_type":"NCID"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"岩泉, 守哉"}],"nameIdentifiers":[{"nameIdentifier":"12739","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-12-02"}],"displaytype":"detail","filename":"臨床化学-49-111.pdf","filesize":[{"value":"2.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"臨床化学-49-111.pdf","url":"https://hama-med.repo.nii.ac.jp/record/4103/files/臨床化学-49-111.pdf"},"version_id":"6009358b-7839-4031-8b9f-62e4e47b1fa9"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"マイクロサテライト不安定性","subitem_subject_scheme":"Other"},{"subitem_subject":"MSI検査","subitem_subject_scheme":"Other"},{"subitem_subject":"DNAミスマッチ修復機構","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"DNAミスマッチ修復機構からみた大腸癌治療の感受性変化","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"DNAミスマッチ修復機構からみた大腸癌治療の感受性変化","subitem_title_language":"ja"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-12-02"},"publish_date":"2022-12-02","publish_status":"0","recid":"4103","relation_version_is_last":true,"title":["DNAミスマッチ修復機構からみた大腸癌治療の感受性変化"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-08-02T07:17:55.583283+00:00"}