{"created":"2023-06-20T15:49:31.039635+00:00","id":4105,"links":{},"metadata":{"_buckets":{"deposit":"4ba88f0a-aec7-4b06-af77-bea9b1801272"},"_deposit":{"created_by":4,"id":"4105","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"4105"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00004105","sets":["1:11"]},"author_link":["12756","12757","12758","12759","12760","12761","12762","12763","12764","12765","12766","12767","12768","12769","12770"],"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"836","bibliographicPageStart":"827","bibliographicVolumeNumber":"59","bibliographic_titles":[{"bibliographic_title":"Respiratory Investigation"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is a devastating and life-threatening condition during its clinical course. Biomarkers for precisely anticipating the prognosis of AE-IPF remain to be fully established. The objective of this study was to clarify whether S100A8 and S100A9, which are calcium-binding proteins mainly produced by activated neutrophils, are significant prognostic biomarkers in AE-IPF.\nMethods: Thirty-seven patients with AE-IPF who were diagnosed and treated at our hospital were retrospectively evaluated. The serum levels of S100A8 and S100A9 were measured using enzyme-linked immunosorbent assay, and the relationships between these levels and clinical parameters or prognosis were evaluated.\nResults: The serum levels of S100A8 (median 386.5ng/mL) and S100A9 (median 60.2ng/mL) in patients with AE-IPF were significantly higher than those in age-matched healthy controls and in patients at IPF diagnosis (p<0.001 for all combinations). The serum levels of S100A8 negatively correlated with percent forced vital capacity (r=?0.356, p=0.049) and positively correlated with peripheral white blood cell number (r=0.509, p=0.002). Immunohistochemical staining of autopsy lung specimens showed that neutrophils, present mainly in the alveolar septum, were positive for S100A8 and S100A9. Patients with AE-IPF with higher levels of S100A8 or S100A9 showed significantly worse 3-month survival than those with lower levels (log-rank test, both p=0.028). Finally, in multivariate analysis, the serum levels of both S100A8 and S100A9 were significant prognostic factors (hazard ratio 4.032, p=0.023 and hazard ratio 4.327, p=0.012).\nConclusion: The serum levels of S100A8 and S100A9 at AE were significant prognostic biomarkers in patients with AE-IPF.","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"},{"subitem_publisher":"日本呼吸器学会 = The Japanese Respiratory Society"}]},"item_3_relation_26":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"34154976","subitem_relation_type_select":"PMID"}}]},"item_3_relation_28":{"attribute_name":"出版社DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.resinv.2021.05.008","subitem_relation_type_select":"DOI"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright?2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license?https://creativecommons.org/licenses/by-nc-nd/4.0/"},{"subitem_rights":"\"This is the accepted manuscript version. The formal published version is available at \"\"https://doi.org//10.1016/j.resinv.2021.05.008\"\".\""}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2212-5345","subitem_source_identifier_type":"ISSN"}]},"item_3_source_id_20":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"2212-5353","subitem_source_identifier_type":"ISSN"}]},"item_3_source_id_23":{"attribute_name":"NII書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA12579673","subitem_source_identifier_type":"NCID"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tanaka, Kazuki"}],"nameIdentifiers":[{"nameIdentifier":"12756","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Enomoto, Noriyuki"}],"nameIdentifiers":[{"nameIdentifier":"12757","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hozumi, Hironao"}],"nameIdentifiers":[{"nameIdentifier":"12758","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Isayama, Takuya"}],"nameIdentifiers":[{"nameIdentifier":"12759","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Naoi, Hyogo"}],"nameIdentifiers":[{"nameIdentifier":"12760","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aono, Yuya"}],"nameIdentifiers":[{"nameIdentifier":"12761","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Katsumata, Mineo"}],"nameIdentifiers":[{"nameIdentifier":"12762","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yasui, Hideki"}],"nameIdentifiers":[{"nameIdentifier":"12763","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Karayama, Masato"}],"nameIdentifiers":[{"nameIdentifier":"12764","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Yuzo"}],"nameIdentifiers":[{"nameIdentifier":"12765","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furuhashi, Kazuki"}],"nameIdentifiers":[{"nameIdentifier":"12766","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujisawa, Tomoyuki"}],"nameIdentifiers":[{"nameIdentifier":"12767","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Inui, Naoki"}],"nameIdentifiers":[{"nameIdentifier":"12768","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakamura, Yutaro"}],"nameIdentifiers":[{"nameIdentifier":"12769","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suda, Takafumi"}],"nameIdentifiers":[{"nameIdentifier":"12770","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-12-14"}],"displaytype":"detail","filename":"Respir Investig-59-827.pdf","filesize":[{"value":"9.3 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"Respir Investig-59-827.pdf","url":"https://hama-med.repo.nii.ac.jp/record/4105/files/Respir Investig-59-827.pdf"},"version_id":"0cba944e-c1fa-4e55-b745-8aea3820d5df"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"S100A8","subitem_subject_scheme":"Other"},{"subitem_subject":"S100A9","subitem_subject_scheme":"Other"},{"subitem_subject":"Calgranulin","subitem_subject_scheme":"Other"},{"subitem_subject":"Acute exacerbation","subitem_subject_scheme":"Other"},{"subitem_subject":"Idiopathic pulmonary fibrosis","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Serum S100A8 and S100A9 as prognostic biomarkers in acute exacerbation of idiopathic pulmonary fibrosis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Serum S100A8 and S100A9 as prognostic biomarkers in acute exacerbation of idiopathic pulmonary fibrosis","subitem_title_language":"en"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-12-07"},"publish_date":"2022-12-07","publish_status":"0","recid":"4105","relation_version_is_last":true,"title":["Serum S100A8 and S100A9 as prognostic biomarkers in acute exacerbation of idiopathic pulmonary fibrosis"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-08-02T07:18:00.278925+00:00"}