{"created":"2023-06-20T15:49:31.839933+00:00","id":4117,"links":{},"metadata":{"_buckets":{"deposit":"3664048c-dec1-467f-b92f-c1033c44a998"},"_deposit":{"created_by":4,"id":"4117","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"4117"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00004117","sets":["1:11"]},"author_link":["12806","12814","12815","12816","12853","12817","12818","12819","12820","12821","12822","12823","12824","12825","12826","12827"],"item_3_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"CIRBP in IPF"}]},"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"2157","bibliographicPageStart":"2149","bibliographicVolumeNumber":"160","bibliographic_titles":[{"bibliographic_title":"Chest"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is associated with a poor prognosis with variable clinical course. Early identification of patients at high risk for disease progression and death would lead to early therapeutic intervention and thereby improvement of outcomes. Cold-inducible RNA-binding protein (CIRBP) is produced in response to cellular stresses, which is implicated in multiple biological processes, including cell survival and proliferation.\nRESEARCH QUESTION: Is CIRBP a useful biomarker for predicting the outcomes of patients with IPF?\nSTUDY DESIGN AND METHODS: This study included 95 and 93 patients with IPF from two independent hospitals (derivation and validation cohorts, respectively). The association s of serum CIRBP level upon IPF diagnosis with disease progression within 1 year after diagnosis (i.e. ?10% relative decline in percent predicted forced vital capacity or death) and all-cause mortality were retrospectively analysed. Discrimination performances for predicting these outcomes were evaluated using the c-index. \nRESULTS: Serum and lung tissue CIRBP levels were higher in patients with IPF than in control subjects. In the derivation cohort, the CIRBP high sub-group had significantly higher 1-year disease progression rates and lower cumulative survival rates than the CIRBP low sub-group, and the results were replicated in the validation cohort. In multivariate analyses, high serum CIRBP level was independently associated with higher 1-year disease progression and all-cause mortality rates in both cohorts. Combining the Gender-Age-Physiology and serum CIRBP models improved the c-indices for predicting 1-year disease progression and all-cause mortality compared with that of each model alone. The c-indices of serum CIRBP were particularly high in patients with Gender-Age-Physiology stage I.\nINTERPRETATION: This study successfully validated that serum CIRBP level was an independent predictor of 1-year disease progression and all-cause mortality in IPF. CIRBP is a promising biomarker that can help identify high-risk patients with IPF, especially in the early stage.","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"},{"subitem_publisher":"American College of Chest Physicians"}]},"item_3_relation_26":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"34252438","subitem_relation_type_select":"PMID"}}]},"item_3_relation_28":{"attribute_name":"出版社DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.chest.2021.06.067","subitem_relation_type_select":"DOI"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license?https://creativecommons.org/licenses/by-nc-nd/4.0/"},{"subitem_rights":"\"This is the accepted manuscript version. The formal published version is available at \"\"https://doi.org/10.1016/j.chest.2021.06.067\"\".\""}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0012-3692","subitem_source_identifier_type":"ISSN"}]},"item_3_source_id_20":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"1931-3543","subitem_source_identifier_type":"ISSN"}]},"item_3_source_id_23":{"attribute_name":"NII書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA00603511","subitem_source_identifier_type":"NCID"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hozumi, Hironao"}],"nameIdentifiers":[{"nameIdentifier":"12806","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kataoka, Kensuke"}],"nameIdentifiers":[{"nameIdentifier":"12814","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kondoh, Yasuhiro"}],"nameIdentifiers":[{"nameIdentifier":"12815","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Isayama, Takuya"}],"nameIdentifiers":[{"nameIdentifier":"12816","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okada, Jun"}],"nameIdentifiers":[{"nameIdentifier":"12853","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sugiura, Katsunori"}],"nameIdentifiers":[{"nameIdentifier":"12817","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mori, Kazutaka"}],"nameIdentifiers":[{"nameIdentifier":"12818","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kono, Masato"}],"nameIdentifiers":[{"nameIdentifier":"12819","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Yuzo"}],"nameIdentifiers":[{"nameIdentifier":"12820","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Karayama, Masato"}],"nameIdentifiers":[{"nameIdentifier":"12821","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furuhashi, Kazuki"}],"nameIdentifiers":[{"nameIdentifier":"12822","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Enomoto, Noriyuki"}],"nameIdentifiers":[{"nameIdentifier":"12823","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujisawa, Tomoyuki"}],"nameIdentifiers":[{"nameIdentifier":"12824","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Inui, Naoki"}],"nameIdentifiers":[{"nameIdentifier":"12825","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakamura, Yutaro"}],"nameIdentifiers":[{"nameIdentifier":"12826","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suda, Takafumi"}],"nameIdentifiers":[{"nameIdentifier":"12827","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-12-20"}],"displaytype":"detail","filename":"Chest-160-2149.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"Chest-160-2149.pdf","url":"https://hama-med.repo.nii.ac.jp/record/4117/files/Chest-160-2149.pdf"},"version_id":"4ca63846-cd2e-4e07-bbfa-b243a075256d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Biomarker","subitem_subject_scheme":"Other"},{"subitem_subject":"Cold-inducible RNA-binding protein","subitem_subject_scheme":"Other"},{"subitem_subject":"Disease progression","subitem_subject_scheme":"Other"},{"subitem_subject":"Idiopathic pulmonary fibrosis","subitem_subject_scheme":"Other"},{"subitem_subject":"Prognosis","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Clinical significance of cold-inducible RNA-binding protein in idiopathic pulmonary fibrosis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Clinical significance of cold-inducible RNA-binding protein in idiopathic pulmonary fibrosis","subitem_title_language":"en"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-12-16"},"publish_date":"2022-12-16","publish_status":"0","recid":"4117","relation_version_is_last":true,"title":["Clinical significance of cold-inducible RNA-binding protein in idiopathic pulmonary fibrosis"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-08-02T07:18:01.896904+00:00"}