{"created":"2023-06-20T15:49:33.150491+00:00","id":4136,"links":{},"metadata":{"_buckets":{"deposit":"99585878-ece3-4e07-9cb2-78aea06065c5"},"_deposit":{"created_by":4,"id":"4136","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"4136"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00004136","sets":["1:11"]},"author_link":["12865","12863","12861","12856","12860","12864","12862","12858","12859","12857"],"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"301","bibliographicPageStart":"289","bibliographicVolumeNumber":"40","bibliographic_titles":[{"bibliographic_title":"Forensic Toxicology"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose The aim of this study is to investigate the stabilities of the 24 synthetic cannabinoid metabolites (SCMs) in blood and urine at various temperatures from –30 to 37℃ stored for 1 to 168 days. In addition, experiments of stabilities at lower temperatures and for much longer duration have been performed as described below.\nMethods The quantification was performed by liquid chromatography–tandem mass spectrometry (LC–MS/MS). The blank blood and urine spiked with SCMs and non-spiked real case (authentic) specimens were incubated at 37℃ up to 56 days and at 22, 4 or –30℃ up to 168 days. The non-spiked authentic blood and urine specimens were also stored at –30 or –80℃ for 1, 3 or 5 years to investigate stabilities during very long time frames.\nResults All the 24 SCMs were much more stable in urine than in blood at 37, 22 or 4℃. All 24 SCMs spiked into blood or urine were stable at –30℃ for up to 168 days. The 6 SCMs in the authentic specimens exhibited long stabilities at –30 or –80℃ for 3 to 5 years. Some tendencies were observed according to the relation between the structures of SCMs and their stabilities.\nConclusions The long-term stabilities of 24 SCMs in spiked samples and those of 6 SCMs in the authentic specimens were examined using LC–MS/MS. SCMs were largely very stable and usable several years after storage at –30 or –80℃.","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature"},{"subitem_publisher":"日本法中毒学会 = Japanese Association of Forensic Toxicology"}]},"item_3_relation_26":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"36454405","subitem_relation_type_select":"PMID"}}]},"item_3_relation_28":{"attribute_name":"出版社DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/s11419-022-00613-1","subitem_relation_type_select":"DOI"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s11419-022-00613-1"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1860-8965","subitem_source_identifier_type":"ISSN"}]},"item_3_source_id_20":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"1860-8973","subitem_source_identifier_type":"ISSN"}]},"item_3_source_id_23":{"attribute_name":"NII書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA12435006","subitem_source_identifier_type":"NCID"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Minakata, Kayoko"}],"nameIdentifiers":[{"nameIdentifier":"12856","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hasegawa, Koutaro"}],"nameIdentifiers":[{"nameIdentifier":"12857","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nozawa, Hideki"}],"nameIdentifiers":[{"nameIdentifier":"12858","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamagishi, Itaru"}],"nameIdentifiers":[{"nameIdentifier":"12859","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miyoshi, Naotomo"}],"nameIdentifiers":[{"nameIdentifier":"12860","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Masako"}],"nameIdentifiers":[{"nameIdentifier":"12861","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kitamoto, Takuya"}],"nameIdentifiers":[{"nameIdentifier":"12862","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kondo, Minako"}],"nameIdentifiers":[{"nameIdentifier":"12863","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Watanabe, Kanako"}],"nameIdentifiers":[{"nameIdentifier":"12864","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Osamu"}],"nameIdentifiers":[{"nameIdentifier":"12865","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-02-22"}],"displaytype":"detail","filename":"Forensic Toxicol-40-289.pdf","filesize":[{"value":"2.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Forensic Toxicol-40-289.pdf","url":"https://hama-med.repo.nii.ac.jp/record/4136/files/Forensic Toxicol-40-289.pdf"},"version_id":"9326ae9a-baa0-47bd-b28f-0313b8396e77"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Synthetic cannabinoid metabolite","subitem_subject_scheme":"Other"},{"subitem_subject":"Long-term stability","subitem_subject_scheme":"Other"},{"subitem_subject":"Blood and urine","subitem_subject_scheme":"Other"},{"subitem_subject":"Human authentic specimens","subitem_subject_scheme":"Other"},{"subitem_subject":"Deep-freezing","subitem_subject_scheme":"Other"},{"subitem_subject":"LC–MS/MS","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Long-term stability of 24 synthetic cannabinoid metabolites spiked into whole blood and urine for up to 168 days, and the comparable study for the 6 metabolites in non-spiked real case specimens stored for several years","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Long-term stability of 24 synthetic cannabinoid metabolites spiked into whole blood and urine for up to 168 days, and the comparable study for the 6 metabolites in non-spiked real case specimens stored for several years"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"公開日","attribute_value":"2023-01-13"},"publish_date":"2023-01-13","publish_status":"0","recid":"4136","relation_version_is_last":true,"title":["Long-term stability of 24 synthetic cannabinoid metabolites spiked into whole blood and urine for up to 168 days, and the comparable study for the 6 metabolites in non-spiked real case specimens stored for several years"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-06-20T16:16:48.361410+00:00"}