{"created":"2023-06-20T15:45:55.778892+00:00","id":424,"links":{},"metadata":{"_buckets":{"deposit":"e8f976b2-ed7a-4b8d-bfda-2c4dead0a05d"},"_deposit":{"created_by":4,"id":"424","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"424"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00000424","sets":["1:11"]},"author_link":["994","995","996","997","998","999","1000"],"control_number":"424","item_3_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Trypanosoma congolense急性感染期マウスにおけるCD4/CD25陽性T細胞の役割 (寄生虫病学)","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"【Parasitology】","subitem_alternative_title_language":"en"}]},"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-08-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"759","bibliographicPageStart":"751","bibliographicVolumeNumber":"70","bibliographic_titles":[{"bibliographic_title":"The Journal of Veterinary Medical Science","bibliographic_titleLang":"en"},{"bibliographic_title":"日本獣醫學会会誌","bibliographic_titleLang":"ja"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Despite the immense socio-economic repercussions of African trypanosomosis (AT), there is currently no effective control measure against the disease. Characterization of mechanisms governing resistance and/or susceptibility to AT could suggest interventions that might lead to more effective disease control. The present study was designed in an attempt to address the possible role of CD4^+CD25^+ T cells during an acute lethal infection of mice with Trypanosoma congolense, the causative agent of AT in domestic animals, through selective depletion using anti-CD25 monoclonal antibody. Accordingly, CD4^+CD25^+ T-cell-depletion resulted in a significant reduction or delay in parasitemia, pathology, and mortality, as compared to controls. The apparent resistance in CD4^+CD25^+ T-cell-depleted mice correlated with a profound suppression of Th2 cytokines in vitro and in vivo, culminating in a net Th1 cytokine environment. Cumulatively, these findings suggest that CD4^+CD25^+ T-cell-depletion improves the trypanotolerance of highly susceptible BALB/c mice acutely infected with the lethal T. congolense.","subitem_description_language":"en","subitem_description_type":"Abstract"},{"subitem_description":"アフリカトリパノソーマ症 (AT) は家畜およびヒトの健康を著しく損なう、獣医学および医学上きわめて重要な熱帯原虫病である．しかしながらATに有効なワクチンおよび安全な治療薬はない．野生動物やアフリカ在来品種のウシではATに自然抵抗性を有することが知られているが、獲得免疫によるAT抵抗性メカニズムは不明である．本研究ではTrypanosoma congolense (Tc) 急性感染期マウスにおけるCD4/CD25陽性T細胞の役割を、抗CD25モノクローナル抗体 (抗CD25) 処置によって同細胞群を選択的に排除することで解析した．その結果,抗CD25処置群では感染初期の末梢血液中におけるTc増殖が有意に抑制され、生存日数の延長が観察された．また、抗CD25処置群のサイトカイン応答ならびにTc抗原特異的抗体応答はいずれも対照群とは逆にTh1タイプに偏っていた．以上の結果はTc感染抵抗性に感染初期のTh1タイプ免疫応答活性化が必要であることを示唆している．","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本獣医学会","subitem_publisher_language":"ja"}]},"item_3_relation_22":{"attribute_name":"NII論文ID","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"110006878921","subitem_relation_type_select":"NAID"}}]},"item_3_relation_26":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"18772548","subitem_relation_type_select":"PMID"}}]},"item_3_relation_27":{"attribute_name":"医中誌論文ID","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"2009002592","subitem_relation_type_select":"ICHUSHI"}}]},"item_3_relation_28":{"attribute_name":"出版社DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1292/jvms.70.751","subitem_relation_type_select":"DOI"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"(C) 日本獣医学会","subitem_rights_language":"ja"},{"subitem_rights":"本文データは学協会の許諾に基づきCiNiiから複製したものである","subitem_rights_language":"ja"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0916-7250","subitem_source_identifier_type":"PISSN"}]},"item_3_source_id_20":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"1347-7439","subitem_source_identifier_type":"EISSN"}]},"item_3_source_id_23":{"attribute_name":"NII書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA10796138","subitem_source_identifier_type":"NCID"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ナマンガラ, ボニフェス","creatorNameLang":"ja"},{"creatorName":"NAMANGALA, Boniface","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"994","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"横山, 直明","creatorNameLang":"ja"},{"creatorName":"YOKOYAMA, Naoaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"995","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"池原, 譲","creatorNameLang":"ja"},{"creatorName":"IKEHARA, Yuzuru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"996","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田口, 修","creatorNameLang":"ja"},{"creatorName":"TAGUCHI, Osamu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"997","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻村, 邦夫","creatorNameLang":"ja"},{"creatorName":"TSUJIMURA, Kunio","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"998","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"杉本, 千尋","creatorNameLang":"ja"},{"creatorName":"SUGIMOTO, Chihiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"999","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"井上, 昇","creatorNameLang":"ja"},{"creatorName":"INOUE, Noboru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1000","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-08-27"}],"displaytype":"detail","filename":"110006878921.pdf","filesize":[{"value":"886.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"110006878921.pdf","objectType":"fulltext","url":"https://hama-med.repo.nii.ac.jp/record/424/files/110006878921.pdf"},"version_id":"071e3353-cb28-4eb2-98e5-20f8a753790b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"CD4[+] CD25[+] T cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"depletion","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Th1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Th2 cytokines","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"trypanosomosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"trypanotolerance","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effect of CD4+CD25+ T Cell-Depletion on Acute Lethal Infection of Mice with Trypanosoma congolense","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effect of CD4+CD25+ T Cell-Depletion on Acute Lethal Infection of Mice with Trypanosoma congolense","subitem_title_language":"en"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-08-27"},"publish_date":"2013-08-27","publish_status":"0","recid":"424","relation_version_is_last":true,"title":["Effect of CD4+CD25+ T Cell-Depletion on Acute Lethal Infection of Mice with Trypanosoma congolense"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2024-04-05T00:30:51.321603+00:00"}