{"created":"2023-06-20T15:49:39.838227+00:00","id":4249,"links":{},"metadata":{"_buckets":{"deposit":"7bdf5fcf-3f1c-4dfa-a494-307b4db4f52d"},"_deposit":{"created_by":4,"id":"4249","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"4249"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00004249","sets":["1:11"]},"author_link":["13086","13087","13088","13089","13090","13091","13092","13093","13094","13095","13096","13097","13098"],"control_number":"4249","item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-07","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"773","bibliographicPageStart":"767","bibliographicVolumeNumber":"27","bibliographic_titles":[{"bibliographic_title":"Journal of Orthopaedic Science","bibliographic_titleLang":"en"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background\nCondoliase-induced chemonucleolysis is a less-invasive alternative treatment for lumbar disc herniation (LDH); however, its long-term clinical outcome is still unclear. This study aimed to investigate 1-year clinical outcomes and assess radiographs after chemonucleolysis with condoliase.\nMethods\nWe enrolled patients with LDH who received condoliase injection with a follow-up period of>1 year. Sixty patients (37 men, 23 women; mean age, 44.5 ± 18.9 years; mean follow-up period, 22.0 ± 6.0 months) were analyzed. Changes in disc height and degeneration were evaluated using magnetic resonance imaging. Visual analog scale (VAS) scores for leg and back pain and the Oswestry disability index (ODI) were obtained. All data were assessed at baseline, 1-month, 3-month, and 1-year follow-up.\nResults\nSurgical treatment was subsequently required in 8 patients (12.5%) after condoliase therapy. Their ODI and VAS scores for leg pain and back pain significantly improved at 1 year, as in those who received condoliase therapy only. On MRI, progression of Pfirrmann grade was observed in 23 patients (44.2%) at 3 months; however, 8 patients recovered to baseline at 1 year. The mean disc height decreased at 3 months; however, it recovered at 1 year. Disc height recovery (disc recovery rate>50%) was observed in 30.8% of the patients. Patients with disc height recovery were significantly younger than those without. Patients with longer symptom duration (≥1 year) showed significantly lower rates of effectiveness compared with those with shorter symptom durations (<1 year).\nConclusions\nChemonucleolysis with condoliase is a safe and minimally invasive treatment. Disc degeneration induced by chemonucleolysis could be recovered, particularly in younger patients. Prolonged symptom duration had adverse effects on outcome; thus, therapeutic intervention at the optimal time is needed.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"},{"subitem_publisher":"日本整形外科学会","subitem_publisher_language":"ja"},{"subitem_publisher":"The Japanese Orthopaedic Association","subitem_publisher_language":"en"}]},"item_3_relation_26":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"34144880","subitem_relation_type_select":"PMID"}}]},"item_3_relation_28":{"attribute_name":"出版社DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.jos.2021.05.005","subitem_relation_type_select":"DOI"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/","subitem_rights_language":"en"},{"subitem_rights":"This is the accepted manuscript version. The formal published version is available at \"https://doi.org/10.1016/j.jos.2021.05.005\".","subitem_rights_language":"en"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0949-2658","subitem_source_identifier_type":"PISSN"}]},"item_3_source_id_20":{"attribute_name":"EISSN","attribute_value_mlt":[{"subitem_source_identifier":"1436-2023","subitem_source_identifier_type":"EISSN"}]},"item_3_source_id_23":{"attribute_name":"NII書誌ID","attribute_value_mlt":[{"subitem_source_identifier":"AA11052566","subitem_source_identifier_type":"NCID"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Banno, Tomohiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13086","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hasegawa, Tomohiko","creatorNameLang":"en"}],"familyNames":[{"familyName":"en"}],"nameIdentifiers":[{"nameIdentifier":"13087","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamato, Yu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13088","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshida, Go","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13089","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Arima, Hideyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13090","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oe, Shin","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13091","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mihara, Yuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13092","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamada, Tomohiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13093","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ide, Koichiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13094","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Watanabe, Yuh","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13095","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kurosu, Kenta","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13096","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakai, Keiichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13097","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsuyama, Yukihiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"13098","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2023-07-07"}],"displaytype":"detail","filename":"J Orthop Sci-27-767.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"J Orthop Sci-27-767.pdf","url":"https://hama-med.repo.nii.ac.jp/record/4249/files/J Orthop Sci-27-767.pdf"},"version_id":"402bfb0f-92d5-480d-8c87-3b72b907317a"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Disc degeneration could be recovered after chemonucleolysis with condoliase. −1 year clinical outcome of condoliase therapy−","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Disc degeneration could be recovered after chemonucleolysis with condoliase. −1 year clinical outcome of condoliase therapy−","subitem_title_language":"en"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-10-02"},"publish_date":"2023-10-02","publish_status":"0","recid":"4249","relation_version_is_last":true,"title":["Disc degeneration could be recovered after chemonucleolysis with condoliase. −1 year clinical outcome of condoliase therapy−"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-10-03T01:22:44.456622+00:00"}