@article{oai:hama-med.repo.nii.ac.jp:00000425,
 author = {岡本, 芳晴 and OKAMOTO, Yoshiharu and 米村, 大輔 and YONEMURA, Daisuke and 宮武, 克行 and MIYATAKE, Katsuyuki and 橋本, 康男 and HASHIMOTO, Yasuo and 平野, 達 and HIRANO, Toru and 阪田, 功 and SAKATA, Isao and 南, 三郎 and MINAMI, Saburo},
 issue = {12},
 journal = {The journal of veterinary medical science, 日本獣醫學会会誌},
 month = {Dec},
 note = {We evaluated changes in hematology and chemical profile, and the tissue retention of hematoporphyrin derivative (HpD) following the intravenous injection in dogs. HpD at concentrations of 1, 5, 10, and 15 mg/kg was intravenously injected to 16 dogs (n=4 each) and complete blood count (CBC) and blood chemistry were performed on days 1, 3, 5, and 7 after the injection. To examine tissue retention, HpD (5 mg/kg) was administered to 15 dogs and 3 dogs were euthanized on days 1, 2, 7, 14, and 28 after the injection, respectively, to collect the skin, muscle, small intestine, spleen, kidney and liver as tissue samples. There were no significant changes in CBC and blood chemical profile except for an increase in LDH concentrations in dogs given 10 and 15 mg/kg of HpD at day 3. The levels of HpD retention in the tissues were ranked in the following order : liver > kidney > spleen > intestine > muscle > skin., 犬において,ヘマトポルフィリン誘導体(HpD)静脈内投与後の血液性状に及ぼす影響および組織残留性について検討した.血液性状については16頭の犬を4群(各群4頭)に分け,1,5,10,15mg/kgのHpDを各群に静脈内投与し,1,3,5,7日後の血液性状を検討した.組織残留性については,犬15頭にHpD(5mg/kg)を静脈内投与後,1,2,7,14,28日目に3頭ずつ安楽死し,皮膚,筋肉,小腸,脾臓,腎臓および肝臓を採取した.その結果,10および15mg/kg投与群で投与後一過性のLDHの上昇がみられた.組織残留量は肝臓>腎臓>脾臓>小腸>筋肉>皮膚の順であった,皮膚残留量から,最低1カ月は日光に暴露させない必要があると考えられた.},
 pages = {1599--1601},
 title = {Tissue Retention and Adverse Reaction after Intravenous Injection of Hematoporphyrin Derivatives in Dogs 【Surgery】},
 volume = {66},
 year = {2004}
}