{"created":"2023-06-20T15:45:59.690352+00:00","id":484,"links":{},"metadata":{"_buckets":{"deposit":"dfca4f42-e7cd-46ba-9189-7daf2d836503"},"_deposit":{"created_by":4,"id":"484","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"484"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00000484","sets":["1:11"]},"author_link":["1268","1269","1270","1271","1272"],"item_3_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Method for Analysis of Robustness properties of Calcium channel on the excitatory cellular membrane by H2 control theory"}]},"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-07-19","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"228","bibliographicPageEnd":"16","bibliographicPageStart":"9","bibliographicVolumeNumber":"101","bibliographic_titles":[{"bibliographic_title":"電子情報通信学会技術研究報告. NLP, 非線形問題 IEICE technical report. Nonlinear problems"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"カルシウムイオンチャンネルの雑音フィルター機能を評価する目的でH2制御方策を提唱した。カルシウムイオンチャンネルの多位相遷移は4つのサブユニットにそれぞれ存在す細胞膜電位感受性分子の位置によって開状態、閉状態それぞれ4とうりを設定した。H2制御理論により、制御器からの出力および制御器からの入力を含めたマトリックス方程式群を導いた。これに対して、雑音入力から信号出力までの閉回路の伝達関数の2ノルムを最小にするべくリッカチ方程式を状態変数と観測器の両者に対して導出した。チャンネルの種々の分子構造状態が単位膜面積に占める量の時間経過はH2制御下ではその変動が著しく低減された。システム方程式中のある特定の重み係数を減少させるとその重み係数が関与するチャンネル状態量の時間経過が大きく変化した。  We have proposed an H2 control principle for evaluating the noise filtering function of the Calcium ion channel on the excitable biological membrane. The multi phase channel properties were characterized by four identical subunits. Each subunit has a voltage sensitive molecule which acts as a gating regulator for channel opening and closing. By applying the H2 control theory, we obtained matrix differential equations including the observer and estimator and two Riccati equations for the observer and state. They minimized the 2 norm of the transfer function from the noise to the out put signal. The concentrations of any channel species per unit membrane area were significantly smoothed under the H2 control. The changes in weighting coefficients induced definite changes in the temporal changes in the species.","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"電子情報通信学会"}]},"item_3_relation_22":{"attribute_name":"NII論文ID","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"110003292507","subitem_relation_type_select":"NAID"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"電子情報通信学会"},{"subitem_rights":"本文データは学協会の許諾に基づきCiNiiから複製したものである"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09135685","subitem_source_identifier_type":"ISSN"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"平山, 博史"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"沖田, 善光"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"杉浦, 敏文"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"木村, 元彦"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"数井, 輝久"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-08-27"}],"displaytype":"detail","filename":"110003292507.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"110003292507.pdf","url":"https://hama-med.repo.nii.ac.jp/record/484/files/110003292507.pdf"},"version_id":"6d8a4593-4be6-472a-b539-727f5fdb67fb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"カルシウムイオンチャンネル","subitem_subject_scheme":"Other"},{"subitem_subject":"ロバスト","subitem_subject_scheme":"Other"},{"subitem_subject":"H2制御","subitem_subject_scheme":"Other"},{"subitem_subject":"雑音入力","subitem_subject_scheme":"Other"},{"subitem_subject":"信号出力","subitem_subject_scheme":"Other"},{"subitem_subject":"リッカチ方程式","subitem_subject_scheme":"Other"},{"subitem_subject":"Calcium ion channel","subitem_subject_scheme":"Other"},{"subitem_subject":"Robust H2 control","subitem_subject_scheme":"Other"},{"subitem_subject":"Noise input","subitem_subject_scheme":"Other"},{"subitem_subject":"Riccati equation","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"興奮性生体膜上のカルシウイオンムチャンネルのロバスト特性解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"興奮性生体膜上のカルシウイオンムチャンネルのロバスト特性解析","subitem_title_language":"ja"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-08-27"},"publish_date":"2013-08-27","publish_status":"0","recid":"484","relation_version_is_last":true,"title":["興奮性生体膜上のカルシウイオンムチャンネルのロバスト特性解析"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-08-02T05:41:27.794802+00:00"}