{"created":"2023-06-20T15:46:00.577957+00:00","id":500,"links":{},"metadata":{"_buckets":{"deposit":"3fd1a1ee-22ff-49aa-9604-baebcade5723"},"_deposit":{"created_by":4,"id":"500","owners":[4],"pid":{"revision_id":0,"type":"depid","value":"500"},"status":"published"},"_oai":{"id":"oai:hama-med.repo.nii.ac.jp:00000500","sets":["1:11"]},"author_link":["1342","1343","1344"],"item_3_alternative_title_1":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Computation of Helmholtz Free Energy in the Channel Modecules on the Biological Membrane."}]},"item_3_biblio_info_5":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2000-12-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"489","bibliographicPageEnd":"24","bibliographicPageStart":"17","bibliographicVolumeNumber":"100","bibliographic_titles":[{"bibliographic_title":"電子情報通信学会技術研究報告. MBE, MEとバイオサイバネティックス IEICE technical report. ME and bio cybernetics"}]}]},"item_3_description_9":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"生体膜上に存在する各種チャンネルの開閉状態遷移の生物物理化学的メカニスムを解明する目的で、チャンネル分子がゆうするヘルムホルツ自由エネルギーを計算する方法を示した。まず最初のステップとして、球状のCavityを形成する場合のポテンシアル計算をDubey-Huckelの強電解液理論をもとに、3層構造モデルを考えた。内層および中間(境界層)層の電場はラプラス方程式で、外層のポテンシアルはポアソン方程式で記述した。球座標を用いて、3層のポテンシアルを計算する方法をしめした。また、離散的分布をする電荷の場合の自由エネルギを単位電荷あたりの値で計算した。内層の相対誘電率が増加すると自由エネルギーは減少した。本研究を発展させると生体チャンネル分子が有する自由エネルギーを推定するのに有益である。  A physical and mathematical method was introduced for analyzing the bio physical- chemical mechanism of transitional changes in opening and closing the channels on the biological membrane. For the first step, we computed the Helmholtz free energy of the channel cavity. In the present work, we assumed that the channel cavity is spherical one to which the spherical coordinates and the Legendre associated functions are easy to apply. The cavity was assumed to composed of three layers, for the inner and the middle layer the potential satisfied the Laplace equation and the outer region, Poisson equation. The free energy decreased as the Di electric constant of the inner region increased. The present method is available for evaluating the thermo dynamical function of the channel molecules when they transit bewtween the open and the close states.","subitem_description_type":"Abstract"}]},"item_3_publisher_6":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"電子情報通信学会"}]},"item_3_relation_22":{"attribute_name":"NII論文ID","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"110003287798","subitem_relation_type_select":"NAID"}}]},"item_3_rights_7":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"電子情報通信学会"},{"subitem_rights":"本文データは学協会の許諾に基づきCiNiiから複製したものである"}]},"item_3_source_id_19":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"09135685","subitem_source_identifier_type":"ISSN"}]},"item_3_version_type_32":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"平山, 博史"}],"nameIdentifiers":[{"nameIdentifier":"1342","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"沖田, 善光"}],"nameIdentifiers":[{"nameIdentifier":"1343","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"数井, 輝久"}],"nameIdentifiers":[{"nameIdentifier":"1344","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-08-27"}],"displaytype":"detail","filename":"110003287798.pdf","filesize":[{"value":"857.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"110003287798.pdf","url":"https://hama-med.repo.nii.ac.jp/record/500/files/110003287798.pdf"},"version_id":"8ff2c17b-cef5-488f-8556-ebbcd0d011f7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"生体膜上","subitem_subject_scheme":"Other"},{"subitem_subject":"チャンネル開閉状態遷移","subitem_subject_scheme":"Other"},{"subitem_subject":"ヘルムホルツ自由エネルギー","subitem_subject_scheme":"Other"},{"subitem_subject":"ポアソン方程式","subitem_subject_scheme":"Other"},{"subitem_subject":"Biological membrane","subitem_subject_scheme":"Other"},{"subitem_subject":"Channel open and close transition","subitem_subject_scheme":"Other"},{"subitem_subject":"Helmholtz free energy","subitem_subject_scheme":"Other"},{"subitem_subject":"Poisson equation","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"生体膜上のチャンネル分子の自由エネルギー計算","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"生体膜上のチャンネル分子の自由エネルギー計算","subitem_title_language":"ja"}]},"item_type_id":"3","owner":"4","path":["11"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2013-08-27"},"publish_date":"2013-08-27","publish_status":"0","recid":"500","relation_version_is_last":true,"title":["生体膜上のチャンネル分子の自由エネルギー計算"],"weko_creator_id":"4","weko_shared_id":-1},"updated":"2023-08-02T05:42:10.521008+00:00"}