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伝統草薬処方剤中の腎障害抑制成分の分離とマウスの実験的糸球体障害に対する抑制効果
http://hdl.handle.net/10271/457
http://hdl.handle.net/10271/457f0d8b7da-63d9-49b5-9eb6-99a2978374bd
名前 / ファイル | ライセンス | アクション |
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110003915532.pdf (1.5 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-08-27 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | 伝統草薬処方剤中の腎障害抑制成分の分離とマウスの実験的糸球体障害に対する抑制効果 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Agkistrodon acutus venom | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | caffeic acid | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | glomerular lesion | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | herbal medicine | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | renal pathology | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
その他のタイトル | ||||||
その他のタイトル | Identification of Effective Component from a Traditional Herbal Medicine and the Inhibitory Effects on Experimental Glomerular Lesion in Mice | |||||
言語 | en | |||||
著者 |
杉本, 弘司
× 杉本, 弘司× 櫻井, 信夫× 藤瀬, 裕× 白沢, 春之× 柴田, 清× ja× 高橋, 利枝× 小森, 由美子× 二改, 俊章× 杉原, 久義 |
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書誌情報 |
ja : 日本獣醫學会会誌 en : The journal of veterinary medical science 巻 54, 号 1, p. 111-118, 発行日 1992-02-15 |
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出版者 | ||||||
言語 | ja | |||||
出版者 | 日本獣医学会 | |||||
権利 | ||||||
言語 | ja | |||||
権利情報 | 日本獣医学会 | |||||
権利 | ||||||
言語 | ja | |||||
権利情報 | 本文データは学協会の許諾に基づきCiNiiから複製したものである | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 草薬処方剤から腎障害の改善に有効な成分の抽出分離を行ない, 精製百歩蛇毒プロテアーゼによるマウスの実験的糸球体腎炎に対する抑制効果を検討した. 草薬処方剤の熱水抽出物を通常の分別法によりエーテルで抽出し, 中性及び塩基性画分と酸性画分に分別した. 酸性画分に有効性がみられたため, さらに, 酸性画分を薄層クロマトグラフイーや分光学的手法を用いて検索した結果, 酸性画分の主要の成分のlつはカフェー酸であることが確認された. また, 市販カフェー酸は, 蛇毒プロテアーゼによるマウスの実験的腎障害に対して抑制効果を示した. これは, カフェー酸により, プロテアーゼの酵素活性の低下した結果と考えられた. カフェー酸は, 病理発生に蛋白分解酵素が関与する腎糸球体障害の予防または抑制効果があると推察された. Effective constituents for renal disease were partially purified from a herbal prescription. The efficacy on renal diseases was examined using an experimental model system of glomerular lesion in mice induced by Agkistrodon acutus venom (Ac_1-P). The extract of boiling water of the herbal prescription (P-3) was first fractionated by ether into an acidic fraction and a mixture of basic and neutral fractions. The acidic fraction was proved to be more effective and then further examined by thin layer chromatography and spectrophotometry. One of the main components was confirmed to be caffeic acid which had inhibitory effect on renal failure in mice by Ac_1-P. This effect was considered to be caused by caffeic acid inhibiting the proteolytic enzyme activity of Ac_1-P. Caffeic acid should thus have prophylactic or inhibitory effect on glomerular disease in which proteolytic enzymes may have pathogenic roles. | |||||
言語 | ja | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09167250 | |||||
NII論文ID | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | NAID | |||||
関連識別子 | 110003915532 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |