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The protective effects of various agents that affect mitochondrial function against Ca2+ overload during Ca2+ paradox were investigated in rat ventricular myocytes. Methods and Results On Ca2+ repletion following Ca2+ depletion, [Ca2+]i increased rapidly, and 90 of 210 cells (43%) died. In viable cells, the increase in [Ca2+]i was lower than in dead cells. KB-R7943 prevented the increase in [Ca2+]i, and completely inhibited cell death. Ruthenium red (RuR), diazoxide (Dz) or cyclosporin A (CsA) prevented cell death (15%, 26% and 17%, respectively; p\u003c0.05), and the protective effect of Dz was abolished by 5- hydroxydecanoate. These agents did not reduce the increase in [Ca2+]i in viable cells or the rate of initial increase in [Ca2+]i in all cells. RuR and Dz decreased [Ca2+]m in skinned myocytes, but CsA did not affect [Ca2+]m. Dz reduced NADH fluorescence, whereas RuR and CsA did not. 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Different Actions of Cardioprotective Agents on Mitochondrial Ca2+ Regulation in a Ca2+ Paradox-Induced Ca2+ Overload
http://hdl.handle.net/10271/1883
http://hdl.handle.net/10271/1883fb6bf2cb-860b-432a-87b8-afd562d707db
名前 / ファイル | ライセンス | アクション |
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CircJ-69-1132.pdf (646.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-08-27 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Different Actions of Cardioprotective Agents on Mitochondrial Ca2+ Regulation in a Ca2+ Paradox-Induced Ca2+ Overload | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Ca2+ overload | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Cardiac myocyte | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Mitochondria | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Mitochondrial permeability transition pore | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | Mitochondrial redox state | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
その他のタイトル | ||||||
その他のタイトル | Ca2+ paradox誘導Ca2+過負荷ミトコンドリアのCa2+調節に対する心保護剤の様々な作用 | |||||
言語 | ja | |||||
著者 |
Matsunaga, Masaki
× Matsunaga, Masaki× Saotome, Masao× Satoh, Hiroshi× Katoh, Hideki× Terada, Hajime× Hayashi, Hideharu |
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書誌情報 |
en : Circulation Journal 巻 69, 号 9, p. 1132-1140, 発行日 2005-08-20 |
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出版者 | ||||||
言語 | en | |||||
出版者 | THE JAPANESE CIRCULATION SOCIETY | |||||
権利 | ||||||
言語 | en | |||||
権利情報 | Copyright 2005 THE JAPANESE CIRCULATION SOCIETY | |||||
権利 | ||||||
言語 | ja | |||||
権利情報 | 本文データは学協会の許諾に基づきCiNiiから複製したものである | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background Mitochondrial Ca2+ overload is a major cause of irreversible cell injury during various metabolic stresses. The protective effects of various agents that affect mitochondrial function against Ca2+ overload during Ca2+ paradox were investigated in rat ventricular myocytes. Methods and Results On Ca2+ repletion following Ca2+ depletion, [Ca2+]i increased rapidly, and 90 of 210 cells (43%) died. In viable cells, the increase in [Ca2+]i was lower than in dead cells. KB-R7943 prevented the increase in [Ca2+]i, and completely inhibited cell death. Ruthenium red (RuR), diazoxide (Dz) or cyclosporin A (CsA) prevented cell death (15%, 26% and 17%, respectively; p<0.05), and the protective effect of Dz was abolished by 5- hydroxydecanoate. These agents did not reduce the increase in [Ca2+]i in viable cells or the rate of initial increase in [Ca2+]i in all cells. RuR and Dz decreased [Ca2+]m in skinned myocytes, but CsA did not affect [Ca2+]m. Dz reduced NADH fluorescence, whereas RuR and CsA did not. Conclusions The protective effects of RuR and Dz could be ascribed to altered Ca2+ regulation by decreasing [Ca2+]m, and Dz could have an additional effect on oxidative phosphorylation. The protective effect of CsA could be directly associated with the mitochondrial permeability transition pore. | |||||
言語 | en | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13469843 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13474820 | |||||
NII論文ID | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | NAID | |||||
関連識別子 | 110002703852 | |||||
出版社DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1253/circj.69.1132 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |