| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
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|
タイトル |
Different Actions of Cardioprotective Agents on Mitochondrial Ca2+ Regulation in a Ca2+ Paradox-Induced Ca2+ Overload |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
Ca2+ overload |
| キーワード |
|
|
主題 |
Cardiac myocyte |
| キーワード |
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|
主題 |
Mitochondria |
| キーワード |
|
|
主題 |
Mitochondrial permeability transition pore |
| キーワード |
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|
主題 |
Mitochondrial redox state |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| その他のタイトル |
|
|
その他のタイトル |
Ca2+ paradox誘導Ca2+過負荷ミトコンドリアのCa2+調節に対する心保護剤の様々な作用 |
| 著者 |
Matsunaga, Masaki
Saotome, Masao
Satoh, Hiroshi
Katoh, Hideki
Terada, Hajime
Hayashi, Hideharu
|
| 書誌情報 |
en : Circulation Journal
巻 69,
号 9,
p. 1132-1140,
発行日 2005-08-20
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| 出版者 |
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出版者 |
THE JAPANESE CIRCULATION SOCIETY |
|
言語 |
en |
| 権利 |
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|
権利情報 |
Copyright 2005 THE JAPANESE CIRCULATION SOCIETY |
| 権利 |
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|
権利情報 |
本文データは学協会の許諾に基づきCiNiiから複製したものである |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Background Mitochondrial Ca2+ overload is a major cause of irreversible cell injury during various metabolic stresses. The protective effects of various agents that affect mitochondrial function against Ca2+ overload during Ca2+ paradox were investigated in rat ventricular myocytes. Methods and Results On Ca2+ repletion following Ca2+ depletion, [Ca2+]i increased rapidly, and 90 of 210 cells (43%) died. In viable cells, the increase in [Ca2+]i was lower than in dead cells. KB-R7943 prevented the increase in [Ca2+]i, and completely inhibited cell death. Ruthenium red (RuR), diazoxide (Dz) or cyclosporin A (CsA) prevented cell death (15%, 26% and 17%, respectively; p<0.05), and the protective effect of Dz was abolished by 5- hydroxydecanoate. These agents did not reduce the increase in [Ca2+]i in viable cells or the rate of initial increase in [Ca2+]i in all cells. RuR and Dz decreased [Ca2+]m in skinned myocytes, but CsA did not affect [Ca2+]m. Dz reduced NADH fluorescence, whereas RuR and CsA did not. Conclusions The protective effects of RuR and Dz could be ascribed to altered Ca2+ regulation by decreasing [Ca2+]m, and Dz could have an additional effect on oxidative phosphorylation. The protective effect of CsA could be directly associated with the mitochondrial permeability transition pore. |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
13469843 |
| EISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
13474820 |
| NII論文ID |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
NAID |
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関連識別子 |
110002703852 |
| 出版社DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1253/circj.69.1132 |
| 著者版フラグ |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
CircJ-69-1132.pdf (646.2 kB)
