| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
|
|
タイトル |
ジヒドロピリジン系カルシウム拮抗剤並びに光分解生成物の正イオン・負イオン質量分析 |
|
言語 |
ja |
| 言語 |
|
|
言語 |
jpn |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| その他のタイトル |
|
|
その他のタイトル |
POSITIVE AND NEGATIVE ION MASS SPECTROMETRY AND RAPID EXTRACTION WITH SEPPAK C18 CARTRIDGES FOR DIHYDROPYRIDINE CALCIUM ANTAGONISTS AND THEIR PHOTODECOMPOSITION PRODUCTS |
| 著者 |
熊澤, 武志
妹尾, 洋
鈴木, 修
佐藤, 啓造
|
| 書誌情報 |
ja : 法中毒 = Japanese journal of forensic toxicology
巻 11,
号 2,
p. 128-129,
発行日 1993-05-15
|
| 出版者 |
|
|
出版者 |
日本法中毒学会 |
|
言語 |
ja |
| 権利 |
|
|
権利情報 |
Copyright 日本法中毒学会 |
| 権利 |
|
|
権利情報 |
本文データは日本法中毒学会の許諾のもと掲載しています。 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Positive-ion electron impact (PIEI), positive-ion chemical ionization (PICI) and negative-ion chemical ionization (NICI) mass spectra of nifedipine, nisoldipine, nitrendipine, dehydronitrosonifedipine and dehydronitrosonisoldipine, were presented, and each fragment mode was analyzed. In the PIEI mode, molecular cations appeared in all compounds, though they were small. In the PICI mode, [M+1]+ quasi-molecular cations together with [M+C2H5]+ ions and many fragment ions, appeared. In the NICI mode, the number of peaks was much less than that in both positive modes; intense molecular anions were observed for nifedipine, nisoldipine and nitrendipine, which seem very useful for sensitive and specific detection by gas chromatography (GC)/mass spectrometry (MS) in the NICI mode. Nifedipine, nisoldipine and nitrendipine, which had been added to body fluid samples, could be rapidly extracted by the use of Sep-Pak C18 cartridges. They could be detected both with and without photodecomposition by capillary GC with a DB-1 column, with satisfactory separation and recovery. We recommend the analytical method with photodecomposition, because no special care for light is required during the whole procedure. |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
09159606 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
FT-11-128.pdf (146.7 kB)
