| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
|
|
タイトル |
新しいHPLCカラムを用いたヒト体液中ハロペリドールとその代謝物の迅速分析 |
|
言語 |
ja |
| 言語 |
|
|
言語 |
jpn |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| その他のタイトル |
|
|
その他のタイトル |
RAPID ANALYSIS OF HALOPERIDOLAND ITS METABOLITES IN HUMAN BODY FLUIDS USING A NEW TYPE OF HPLC COLUMN |
| 著者 |
有信, 哲哉
服部, 秀樹
妹尾, 洋
石井, 晃
熊澤, 武志
仙石, 光彦
鈴木, 修
|
| 書誌情報 |
ja : 法中毒
en : Japanese journal of forensic toxicology
巻 19,
号 2,
p. 156-157,
発行日 2001-05-15
|
| 出版者 |
|
|
出版者 |
日本法中毒学会 |
|
言語 |
ja |
| 権利 |
|
|
権利情報 |
Copyright 日本法中毒学会 |
| 権利 |
|
|
権利情報 |
本文データは日本法中毒学会の許諾のもと掲載しています。 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Haloperidol and its two metabolites, reduced haloperidol and 4-(4-Chlorophenyl)-4-hydroxypiperidiene (CPHP), contained in human plasma and urine were analyzed by using a new type of HPLC column (MSpak GF-310) for direct injection of biological samples without complicated pretreatment, and they were determined by means of high-performance liquid chromatography (HPLC)-mass spectrometry (MS). The regression equations of haloperidol, reduced haloperidol and CPHP showed good linearity in the range of 10-800 ng/ml, 15-800 ng/ml and 400-800 ng/ml, respectively, for both plasma and urine. Their detection limits were 5 ng/ml, 10 ng/ml and 300 ng/ml, respectively, for both plasma and urine. We would conclude that the present method was sensitive enough for detection and determination of toxic level for haloperidol in blood, and this approach appears to have a high-potential method for rapid drug analysis from biological samples including biopolymer such as protein. |
| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
09159606 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
FT-19-156.pdf (96.3 kB)
