| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
|
|
タイトル |
PARAQUAT ENHANCES NEPHROCALCINOSIS UNDER MG RESTRICTION IN THE DIET |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
Paraquat |
| キーワード |
|
|
主題 |
Magnesium restriction |
| キーワード |
|
|
主題 |
Calcinosis |
| キーワード |
|
|
主題 |
Kidney |
| キーワード |
|
|
主題 |
Lung |
| キーワード |
|
|
主題 |
Osteogenic disorder Shionogi rats |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| その他のタイトル |
|
|
その他のタイトル |
マグネシウム制限食餌下でのパラコート投与による腎臓石灰化の促進 |
| 著者 |
Minakata, Kayoko
Kawai, Kaori
Horio, Fumihiko
Saito, Shin-ichi
Yamagishi, Itaru
Nozawa, Hideki
Watanabe, Kanako
Suzuki, Osamu
|
| 書誌情報 |
ja : 法中毒
en : Japanese journal of forensic toxicology
巻 21,
号 3,
p. 245-255,
発行日 2003-09-15
|
| 出版者 |
|
|
出版者 |
日本法中毒学会 |
|
言語 |
ja |
| 権利 |
|
|
権利情報 |
Copyright 日本法中毒学会 |
| 権利 |
|
|
権利情報 |
本文データは日本法中毒学会の許諾のもと掲載しています。 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
This study has been undertaken to determine which organs are damaged by herbicide paraquat (PQ) under restriction of Mg and other minerals. Experiments were made with osteogenic disorder Shionogi rats, which lack the ability of synthesizing vitamin C like humans. The dietary Mg or mineral-mixture was given to the rats according to either the concentration or half of it recommended by American Institute of Nutrition. The dose of PQ was either 483 or 965 nmol/g diet. The concentrations of PQ, vitamin C radical and kininogen in tissues or plasma were measured to assess the severity of injury. Tissue levels of several metals, such as Mg, Ca, Fe, Cu and Zn, were also quantitated, because severe PQ toxicity appeared under Mg restriction or the mineral-mixture restriction showing the close relation between PQ toxicity and metals. The most notable change in metal levels caused by the synergistic effect of restriction of either Mg or the mineral-mixture plus dosing of PQ appeared for kidney Ca; the concentration of kidney Ca increased 10 times the control value under Mg restriction and 28 times the control value under the mineral-mixture restriction. The kidney PQ level of the Mg restricted or the mineral-mixture restricted rats was higher than that of the rats dosed with larger amounts of PQ under sufficient mineral supply. These results indicate that the kidney is the target organ of PQ under Mg restriction or mineral-mixture restriction, and suitable amounts of minerals in the diet are useful to reduce chronic PQ toxicity. |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
09159606 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
FT-21-245.pdf (530.4 kB)
