| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
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|
タイトル |
MANGANESE LEVELS IN TISSUES OF PARAQUAT DOSED AND/OR MAGNESIUM RESTRICTED RATS MEASURED BY AN ELECTRON SPIN RESONANCE METHOD |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
Manganese |
| キーワード |
|
|
主題 |
Electron spin resonance |
| キーワード |
|
|
主題 |
ESR |
| キーワード |
|
|
主題 |
Paraquat dosing |
| キーワード |
|
|
主題 |
Magnesium restriction |
| キーワード |
|
|
主題 |
Osteogenic disorder Shionogi rat |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| その他のタイトル |
|
|
その他のタイトル |
ESR測定によるパラコート投与およびマグネシウム制限食投与ラットの組織中マンガン濃度 |
| 著者 |
Minakata, Kayoko
Horio, Fumihiko
Saito, Shin-ichi
Nozawa, Hideki
Watanabe, Kanako
Suzuki, Osamu
|
| 書誌情報 |
ja : 法中毒
en : Japanese journal of forensic toxicology
巻 22,
号 3,
p. 193-195,
発行日 2004-09-15
|
| 出版者 |
|
|
出版者 |
日本法中毒学会 |
|
言語 |
ja |
| 権利 |
|
|
権利情報 |
Copyright 日本法中毒学会 |
| 権利 |
|
|
権利情報 |
本文データは日本法中毒学会の許諾のもと掲載しています。 |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
The effects of drugs and nutritions on tissue manganese (Mn) levels have not been well studied, because of the quite low levels of Mn in mammalian tissues. Furthermore, Mn-complexes with chelators are so unstable that colorimetric assays of the Mncomplexes are interfered with by metal ions commonly present in tissues. To measure such trace amounts of Mn, we have used an electron spin resonance (ESR) method, since Mn2 + is paramagnetic. By this method, Mn2 + could be quantitated using 5μl of its solution at 100 ppb with the error of 5%. The effects of paraquat dosing and/or magnesium (Mg) restriction in the diets for 8 days on tissue Mn and Mg levels were studied using osteogenic disorder Shionogi rats, a mutant strain which cannot synthesize vitamin C like humans. Tissue Mn levels of the animals were not affected by either dosing with paraquat at 125 ppm or Mg restriction at half of that recommended by American Institute of Nutrition-93. When both treatments were given together, however, Mn levels were significantly lowered in the liver, kidney and heart. Mn levels of rats dosed with paraquat at 250 ppm were more significantly lowered in all tissues studied. |
| ISSN |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
09159606 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
FT-22-193.pdf (265.8 kB)
