| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
|
|
タイトル |
SENSITIVE DETERMINATION OF ACETONITRILE AND PROPIONITRILE IN HUMAN WHOLE BLOOD BY HEADSPACE CAPILLARY GAS CHROMATOGRAPHY WITH CRYOGENIC OVEN TRAPPING |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
Acetonitrile |
| キーワード |
|
|
主題 |
Propionitrile |
| キーワード |
|
|
主題 |
Gas chromatography |
| キーワード |
|
|
主題 |
Cryogenic oven trapping |
| キーワード |
|
|
主題 |
Flame thermionic detector (FTD) |
| キーワード |
|
|
主題 |
NPD |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| その他のタイトル |
|
|
その他のタイトル |
低温オーブントラッピングキャピラリーガスクロマトグラフィーによるヒト全血中アセトニトリル及びプロピオニトリルの高感度分析 |
| 著者 |
Kaneko, Rina
Fukui, Rena
Watanabe, Kanako
Hirata, Yukari
Hamajima, Makoto
Ishii, Akira
|
| 書誌情報 |
ja : 法中毒
en : Japanese journal of forensic toxicology
巻 23,
号 1,
p. 37-40,
発行日 2005-01-31
|
| 出版者 |
|
|
出版者 |
日本法中毒学会 |
|
言語 |
ja |
| 権利 |
|
|
権利情報 |
Copyright 日本法中毒学会 |
| 権利 |
|
|
権利情報 |
本文データは日本法中毒学会の許諾のもと掲載しています。 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
We have developed a simple and sensitive method for determining acetonitrile and propionitrile in human whole blood using capillary gas chromatography (GC) with cryogenic oven trapping. After heating 0.5 ml of a whole blood sample containing both nitriles and 0.5 ml of distilled water in a 7-ml vial at 75℃ for 15 min, 5 ml of the headspace vapor was drawn into a 10-ml syringe and injected to GC with a flame thermionic detector. A sharp peak was obtained for acetonitrile at -10℃ of the initial oven temperature. The extraction efficiencies for acetonitrile and propionitrile were 0.27 and 0.40%, respectively. For quantitation of acetonitrile, propionitrile was used as internal standard, and vise versa. The calibration curves for both compounds gave good linearity in the range of 0.2-6 μg/ml whole blood. The detection limits (signal to noise ratio = 3) were 0.05μg/ml for acetonitrile and 0.01μg/ml for propionitrile. The coefficients of intra-day variations were 1.0% at 0.4μg/ml and 1.7% at 2μg/ml for acetonitrile; 7.1% at 0.4μg/m1 and 1.0 % at 2μg/ml for propionitrile. This method can be applicable for determining these nitriles in whole blood samples in acute and chronic intoxication cases. |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
09159606 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
FT-23-37.pdf (280.2 kB)
