| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
|
|
タイトル |
日本人集団におけるハーディ・ワインベルグ平衡の検定法について |
|
言語 |
ja |
| 言語 |
|
|
言語 |
jpn |
| キーワード |
|
|
主題 |
DNA polymorphism |
| キーワード |
|
|
主題 |
Short tandem repeat |
| キーワード |
|
|
主題 |
Hardy-Weinberg equilibrim |
| キーワード |
|
|
主題 |
X2 test |
| キーワード |
|
|
主題 |
Exact test |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
勝又, 義直
水谷, 正樹
野澤, 秀樹
打樋, 利英子
山本, 敏充
玉木, 敬二
|
| 書誌情報 |
ja : 日本法医学雑誌
巻 53,
号 2,
p. 218-226,
発行日 1999-06-05
|
| 出版者 |
|
|
出版者 |
日本法医学会 |
|
言語 |
ja |
| 権利 |
|
|
権利情報 |
Copyright 日本法医学会 |
| 権利 |
|
|
権利情報 |
本文データは日本法医学会の許諾のもと掲載しています。 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
In population genetics, the absence of the departure from Hardy-Weinberg equilibrium (HWE) is usually tested when a population study of a certain DNA marker is performed to show the observed allele frequencies represent those of the whole population. The goodness-of- fit test ( X2 test) assuming X2 approximation has frequently been used with classical blood type markers having a few alleles. However, new tests suitable for DNA markers having many alleles, such as homozygosity test, likelihood ratio test and Guo-Thompson's (G-T') exact test, have recently been devised. In the present study, appropriate tests for HWE was studied using population data of 206 Japanese individuals with 9 different short tandem repeat loci. Firstly, we found that the recommendation of NRC II for the treatment of rare allele frequencies (If a bin in the database contains fewer than five entries, it is pooled with adjacent bins so that no bin has fewer than five) is quite reasonable for personal identification in forensic sciences. Secondly, we proposed that homozygosity test, likelihood ratio test and G-T's exact test should be applied altogether and HWE of the sample population should be valid only when all of the three tests were cleared. |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
00471887 |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
LM-53-218.pdf (681.5 kB)
