| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
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タイトル |
Difference in the Cardioprotective Mechanisms Between Ischemic Preconditioning and Pharmacological Preconditioning by Diazoxide in Rat Hearts |
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言語 |
en |
| 言語 |
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言語 |
eng |
| キーワード |
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主題 |
ATP-sensitive potassium channel |
| キーワード |
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主題 |
High-energy phosphates |
| キーワード |
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主題 |
Intracellular pH |
| キーワード |
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主題 |
Mitochondria |
| キーワード |
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主題 |
Reactive oxygen species |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| その他のタイトル |
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その他のタイトル |
ラットの心臓に対するジアゾキシドの虚血プレコンディショニングと薬理学的プレコンディショニングの心保護機序の相違 |
| 著者 |
Wakahara, Nobuyuki
Katoh, Hideki
Yaguchi, Yasuhiro
Uehara, Akihiko
Satoh, Hiroshi
Terada, Hajime
Fujise, Yutaka
Hayashi, Hideharu
|
| 書誌情報 |
en : Circulation Journal
巻 68,
号 2,
p. 156-162,
発行日 2004-01-20
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| 出版者 |
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出版者 |
THE JAPANESE CIRCULATION SOCIETY |
|
言語 |
en |
| 権利 |
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|
権利情報 |
Copyright 2004 THE JAPANESE CIRCULATION SOCIETY |
| 権利 |
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|
権利情報 |
本文データは学協会の許諾に基づきCiNiiから複製したものである |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Background Recent studies have implicated the opening of mitochondrial KATP (mitoKATP) channels and the production of reactive oxygen species (ROS) in the cardioprotective mechanism of ischemic preconditioning (IPC). Methods and Results The involvement of mitoKATP channels and ROS in the cardioprotective effects of both IPC and the mitoKATP channel opener diazoxide (DZ) was investigated in ischemic/reperfused rat hearts. The effects of IPC and DZ on myocardial high-energy phosphate concentrations and intracellular pH (pHi) were also examined using 31P nuclear magnetic resonance spectroscopy. Although both the mitoKATP channel inhibitor 5- hydroxydecanoate and the antioxidant N-acetylcysteine abolished the postischemic recovery of contractile function by DZ, neither of them inhibited that by IPC. IPC attenuated the decline in pHi during ischemia, but DZ did not (6.28±0.04 in IPC, p<0.05, and 6.02±0.05 in DZ vs 6.02±0.06 in control hearts). DZ, but not IPC, reduced the decrease in ATP levels during ischemia (ATP levels at 20-min ischemia: 26.3±3.4% of initial value in DZ, p<0.05, and 8.1±3.0% in IPC vs 15.1±1.3% in control hearts). Conclusions These results suggest that DZ-induced cardioprotection is related to ROS production and reduced ATP degradation during ischemia, whereas attenuated acidification during ischemia is involved in IPC-induced cardioprotection, which is not mediated through mitoKATP channel opening or ROS production. |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
13469843 |
| EISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
13474820 |
| NII論文ID |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
NAID |
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関連識別子 |
110002667499 |
| 出版社DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1253/circj.68.156 |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
CircJ-68-156.pdf (682.6 kB)
