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  1. 学術雑誌論文
  2. 各雑誌掲載論文

Destruction of Dopaminergic Neurons in the Midbrain by 6-Hydroxydopamine Decreases Hippocampal Cell Proliferation in Rats: Reversal by Fluoxetine

http://hdl.handle.net/10271/1910
http://hdl.handle.net/10271/1910
b894e033-f48e-4156-a222-d86182215540
名前 / ファイル ライセンス アクション
plosone2010_5-9260.pdf plosone2010_5-9260.pdf (1.5 MB)
Item type 学術雑誌論文 / Journal Article(1)
公開日 2013-08-27
タイトル
タイトル Destruction of Dopaminergic Neurons in the Midbrain by 6-Hydroxydopamine Decreases Hippocampal Cell Proliferation in Rats: Reversal by Fluoxetine
言語 en
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
著者 Suzuki, Katsuaki

× Suzuki, Katsuaki

en Suzuki, Katsuaki

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Okada, Kyoko

× Okada, Kyoko

en Okada, Kyoko

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Wakuda, Tomoyasu

× Wakuda, Tomoyasu

en Wakuda, Tomoyasu

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Shinmura, Chie

× Shinmura, Chie

en Shinmura, Chie

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Kameno, Yosuke

× Kameno, Yosuke

en Kameno, Yosuke

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Iwata, Keiko

× Iwata, Keiko

en Iwata, Keiko

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Takahashi, Taro

× Takahashi, Taro

en Takahashi, Taro

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Suda, Shiro

× Suda, Shiro

en Suda, Shiro

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Matsuzaki, Hideo

× Matsuzaki, Hideo

en Matsuzaki, Hideo

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Iwata, Yasuhide

× Iwata, Yasuhide

en Iwata, Yasuhide

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Hashimoto, Kenji

× Hashimoto, Kenji

en Hashimoto, Kenji

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Mori, Norio

× Mori, Norio

en Mori, Norio

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書誌情報 en : PLoS One

巻 5, 号 2, p. e9260, 発行日 2010-02-17
出版者
出版者 Public Library of Science
言語 en
権利
権利情報 Copyright Public Library of Science
抄録
内容記述タイプ Abstract
内容記述 Background Non-motor symptoms (e.g., depression, anxiety, and cognitive deficits) in patients with Parkinson disease (PD) precede the onset of the motor symptoms. Although these symptoms do not respond to pharmacological dopamine replacement therapy, their precise pathological mechanisms are currently unclear. The present study was undertaken to examine whether the unilateral 6-hydroxydopamine (6-OHDA) lesion to the substantia nigra pars compacta (SNc), which represents a model of long-term dopaminergic neurotoxicity, could affect cell proliferation in the adult rat brain. Furthermore, we examined the effects of the selective serotonin reuptake inhibitor (SSRI) fluoxetine and the selective noradrenaline reuptake inhibitor maprotiline on the reduction in cell proliferation in the subgranular zone (SGZ) by the unilateral 6-OHDA lesion. Methodology/Principal Findings A single unilateral injection of 6-OHDA into the rat SNc resulted in an almost complete loss of tyrosine hydroxylase (TH) immunoreactivity in the striatum and SNc, as well as in reductions of TH-positive cells and fibers in the ventral tegmental area (VTA). On the other hand, an injection of vehicle alone showed no overt change in TH immunoreactivity. A unilateral 6-OHDA lesion to SNc significantly decreased cell proliferation in the SGZ ipsilateral to the 6-OHDA lesion, but not in the contralateral SGZ or the subventricular zone (SVZ), of rats. Furthermore, subchronic (14 days) administration of fluoxetine (5 mg/kg/day), but not maprotiline significantly attenuated the reduction in cell proliferation in the SGZ by unilateral 6-OHDA lesion. Conclusions/Significance The present study suggests that cell proliferation in the SGZ of the dentate gyrus might be, in part, under dopaminergic control by SNc and VTA, and that subchronic administration of fluoxetine reversed the reduction in cell proliferation in the SGZ by 6-OHDA. Therefore, SSRIs such as fluoxetine might be potential therapeutic drugs for non-motor symptoms as well as motor symptoms in patients with PD, which might be associated with the reduction in cell proliferation in the SGZ.
ISSN
収録物識別子タイプ ISSN
収録物識別子 19326203
出版社DOI
関連タイプ isIdenticalTo
識別子タイプ DOI
関連識別子 10.1371/journal.pone.0009260
著者版フラグ
出版タイプ VoR
出版タイプResource http://purl.org/coar/version/c_970fb48d4fbd8a85
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