| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2013-08-27 |
| タイトル |
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タイトル |
Absence of germline mono-allelic promoter hypermethylation of the CDH1 gene in gastric cancer patients |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Yamada, Hidetaka
Shinmura, Kazuya
Goto, Masanori
Iwaizumi, Moriya
Konno, Hiroyuki
Kataoka, Hideki
Yamada, Masami
Ozawa, Takachika
Tsuneyoshi, Toshihiro
Tanioka, Fumihiko
Sugimura, Haruhiko
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| 書誌情報 |
en : Molecular Cancer
巻 8,
p. 63,
発行日 2009-08-12
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| 出版者 |
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出版者 |
BioMed Central Ltd |
|
言語 |
en |
| 権利 |
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|
権利情報 |
Copyright 2009 BioMed Central Ltd |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Background: Germline mono-allelic promoter hypermethylation of the MLH1 or MSH2 gene in families with hereditary nonpolyposis colorectal cancer has recently been reported. The purpose of this study was to evaluate if germline promoter hypermethylation of the tumor suppressor gene CDH1 (E-cadherin) might cause predisposition to gastric cancer. Methods: We prepared two groups of samples, a group of blood samples from 22 patients with familial gastric cancer or early-onset gastric cancer selected from among 39 patients, and a group of non-cancerous gastric tissue samples from 18 patients with sporadic gastric cancer showing loss of CDH1 expression selected from among 159 patients. We then investigated the allele-specific methylation status of the CDH1 promoter by bisulfite sequencing of multiple clones. Results: Although there was a difference between the methylation level of the two alleles in some samples, there was no mono-allelic promoter hypermethylation in any of the samples. Conclusion: These results suggest that germline mono-allelic hypermethylation of the CDH1 promoter is not a major predisposing factor for gastric cancer. |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
14764598 |
| 出版社DOI |
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関連タイプ |
isIdenticalTo |
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識別子タイプ |
DOI |
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関連識別子 |
10.1186/1476-4598-8-63 |
| 著者版フラグ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
MolCancer2009_8-63.pdf (1.2 MB)
